Intercellular Communication in Ageing and Cancer

Description

The diseases with the highest mortality and incidence in our society are chronic diseases and age-related diseases. Generally, the biological, cellular, and molecular bases of these diseases respond to complex mechanisms determined by multiple factors in space and time. This makes them difficult to study and results in the translation of knowledge we generate to the patient occurring in the long term.

Our group is focused on studying the relationships established by different cells in the context of complex chronic diseases associated with aging of organs and tissues, with a special interest in cancer and fibrosis.

Scientific Objectives and Research lines:

• Describe intercellular relationships in the context of chronic human disease.
• Identify new biomarkers and therapeutic targets.
• Develop new tools for studying these pathologies.

Specific Objectives:

1. Characterize the role of fibroblasts in relation to their environment.
2. Cell-cell and cell-matrix relationships in fibrosis and cancer.
3. III. Study transcription in common pathways in fibrosis and cancer: AP-1 family.
4. Identify relevant mechanisms in chronic inflammation.