Tumour Immunomodulation

Description

GROUP DESCRIPTION

The modulation of the immune system is revolutionizing the fight against cancer and infectious diseases. Recent advances show that an individual’s immune system can be activated to eliminate tumor cells and is capable of responding to agents that reshape the immune response.

STRATEGIC OBJECTIVES

The overall objective of the Tumor Immunomodulation Group is to study the behavior of anti-tumor immunity, from the composition to the function of immune cells and their interaction with tumor cells. Studying the tumor microenvironment in different tumor contexts is crucial for understanding the underlying mechanisms of anti-tumor immune evasion and escape, as well as for the clinical development of immunomodulatory strategies. Our group is highly focused on translational research and the clinical implementation of new therapeutic tools for the treatment of various types of cancer, with a particular focus on lung cancer.

RESEARCH LINES

* Study the predominant mechanisms of immune escape and evasion in lung cancer.
* Explore the anti-tumor response to different immunotherapies, both as monotherapies and in combination.
* Identify new targets for the development of tools that re-educate the immune compartment toward a favorable environment for immunotherapy response.
* Study the interaction between transcriptional stress mechanisms and DNA damage with the immune response.