Thoracic and Clinical-Translational Oncology

Description

The goal of the Research Group in Thoracic and Clinical-Translational Oncology is to characterize thoracic tumors from a molecular viewpoint and to understand the biological mechanisms governing their growth. The research group integrates clinical-translational research with the daily healthcare practice, and is committed to implement the medical advances achieved in the laboratory in standard clinical practice.

Scientific objectives and lines of work

1. Molecular characterization of thoracic neoplasms.
2. Translational development of novel biomarkers.
3. Preclinical evaluation of new therapeutic strategies using patient-derived xenograft (PDX) mouse models.
4. Early clinical trials.
5. Improvements in standard clinical practice in lung cancer.

Specific objectives

1. Molecular characterization of thoracic neoplasms.
   1. Molecular taxonomy of lung cancer
   2. Integral molecular and immunological profiling of non-small cell lung cancer (NSCLC). Design and validation of adapted immunotherapy approaches
2. Translational development of novel biomarkers.
   1. Study of new biomarkers aimed at determining the efficacy of the inhibition of FGFR1/4 as a therapeutic approach for lung cancer
   2. Study of new diagnostic biomarkers of lung cancer
3. Preclinical evaluation of new therapeutic strategies using PDX mouse models.
4. Early clinical trials.
5. Improvements in standard clinical practice in lung cancer.