Surfactante Pulmonar y Enfermedad Respiratoria |

Publicaciones

2025

Collada, A, Cruz, A, Pérez-Gil, J (2025).

Studying the interfacial activity and structure of pulmonary surfactant complexes

CHEMISTRY AND PHYSICS OF LIPIDS. Article. 266.
[doi:10.1016/j.chemphyslip.2024.105459]

2024

Pérez-Gil, J, Frick, M (2024).

Acidic Enough for a Healthy Breath

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Editorial Material. 71(4):383-385.
[doi:10.1165/rcmb.2024-0237ED]

Avcibas R, Vermul A, Gluhovic V, Boback N, Arroyo R, Kingma P, Isasi-Campillo M, Garcia-Ortega L, Griese M, Kuebler WM, Ochs M, Lauster D, Lopez-Rodriguez E (2024).

Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Article. 326(5):524-538.
[doi:10.1152/ajplung.00283.2023]

Xu, Y, Cañadas, O, Alonso, A, Franzyk, H, Thakur, A, Pérez-Gil, J, Foged, C (2024).

Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies

JOURNAL OF COLLOID AND INTERFACE SCIENCE. Article. 654:1111-1123.
[doi:10.1016/j.jcis.2023.10.036]

Moran-Lalangui, M, Coutinho, A, Prieto, M, Fedorov, A, Perez-Gil, J, Loura, LMS, Garcia-alvarez, B (2024).

Exploring protein-protein interactions and oligomerization state of pulmonary surfactant protein C (SP-C) through FRET and fluorescence self-quenching

PROTEIN SCIENCE. Article. 33(1).
[doi:10.1002/pro.4835]

2023

Mishra R, Hannebelle M, Patil VP, Dubois A, Garcia-Mouton C, Kirsch GM, Jan M, Sharma K, Guex N, Sordet-Dessimoz J, Perez-Gil J, Prakash M, Knott GW, Dhar N, McKinney JD, Thacker VV (2023).

Mechanopathology of biofilm-like Mycobacterium tuberculosis cords.

Cell. Article. 186(23):5135.
[doi:10.1016/j.cell.2023.09.016]

Pérez-Gil, J (2023).

Call for Papers: "Alveolar biology, pulmonary surfactant, and beyond": a tribute to Dr. John Allen Clements on his 100th birthday

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Editorial Material. 325(2):244-245.
[doi:10.1152/ajplung.00143.2023]

Isasi-Campillo, M, Losada-Oliva, P, Pérez-Gil, J, Olmeda, B, García-Ortega, L (2023).

Pulmonary surfactant-derived antiviral actions at the respiratory surface

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. Review. 66.
[doi:10.1016/j.cocis.2023.101711]

Feo-Lucas, L, Godio, C, de la Escalera, MM, Alvarez-Ladrón, N, Villarrubia, LH, Vega-Pérez, A, González-Cintado, L, Domínguez-Andrés, J, García-Fojeda, B, Montero-Fernández, C, Casals, C, Autilio, C, Pérez-Gil, J, Crainiciuc, G, Hidalgo, A, López-Bravo, M, Ardavín, C (2023).

Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction

Frontiers in immunology. Article. 14.
[doi:10.3389/fimmu.2023.1125984]

Xu Y, Parra-Ortiz E, Wan F, Cañadas O, Garcia-Alvarez B, Thakur A, Franzyk H, Pérez-Gil J, Malmsten M, Foged C (2023).

Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant.

JOURNAL OF COLLOID AND INTERFACE SCIENCE. Article. 633:511-525.
[doi:10.1016/j.jcis.2022.11.059]

Garcia-Mouton, C, Echaide, M, Serrano, LA, Orellana, G, Salomone, F, Ricci, F, Pioselli, B, Amidani, D, Cruz, A, Perez-Gil, J (2023).

Beyond the Interface: Improved Pulmonary Surfactant-Assisted Drug Delivery through Surface-Associated Structures.

Pharmaceutics. Article. 15(1).
[doi:10.3390/pharmaceutics15010256]

2022

Garcia-Mouton, C, Parra-Ortiz, E, Malmsten, M, Cruz, A, Perez-Gil, J (2022).

Pulmonary surfactant and drug delivery: Vehiculization of a tryptophan-tagged antimicrobial peptide over the air-liquid interfacial highway.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. Article. 180:33-47.
[doi:10.1016/j.ejpb.2022.09.018]

Estrada P, Bañares-Hidalgo Á, Pérez-Gil J (2022).

Disulfide bonds in the SAPA domain of the pulmonary surfactant protein B precursor.

JOURNAL OF PROTEOMICS. Article. 269:104722-104722.
[doi:10.1016/j.jprot.2022.104722]

Pérez-Gil J (2022).

A recipe for a good clinical pulmonary surfactant.

Biomedical Journal. Review. 45(4):615-628.
[doi:10.1016/j.bj.2022.03.001]

De Luca, D, Foligno, S, Autilio, C, Vivanti, A, Vandekerckhove, M, Martinovic, J, Raschetti, R, Guillot, L, Touqui, L (2022).

Secretory phospholipase A2 expression and activity in preterm clinical chorioamnionitis with fetal involvement

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Article. 323(2):121-128.
[doi:10.1152/ajplung.00516.2021]

De Luca D, Alonso A, Autilio C (2022).

Bile acid-induced lung injury: update of reverse translational biology.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Review. 323(1):93-106.
[doi:10.1152/ajplung.00523.2021]

Korolainen H, Lolicato F, Enkavi G, Pérez-Gil J, Kulig W, Vattulainen I (2022).

Dimerization of the pulmonary surfactant protein C in a membrane environment.

PLOS ONE. Article. 17(4).
[doi:10.1371/journal.pone.0267155]

Gallego, N, Pienkos, S, Condon, D, Cruz, A, Ochoa, N, Nevado, J, Arias, P, Agarwal, S, Patel, H, Chakraborty, A, Lapunzina, P, Escribano, P, de Jesus, V, Tenorio, J (2022).

Novel TRAF2 variant and KDR deletion are implicated in the pathogenesis of pulmonary arterial hypertension

EUROPEAN JOURNAL OF HUMAN GENETICS. Meeting Abstract. 30(SUPPL 1):197-198.

Castillo-Sanchez, JC, Roldan, N, Garcia-Alvarez, B, Batllori, E, Galindo, A, Cruz, A, Perez-Gil, J (2022).

The highly packed and dehydrated structure of pre-formed unexposed human pulmonary surfactant isolated from amniotic fluid.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Article. 322(2):191-203.
[doi:10.1152/ajplung.00230.2021]

Castillo-Sánchez JC, Cerrada A, Conde M, Cruz A, Pérez-Gil J (2022).

Compositional, structural and functional properties of discrete coexisting complexes within bronchoalveolar pulmonary surfactant.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1864(1):183808-183808.
[doi:10.1016/j.bbamem.2021.183808]

2021

De Luca, D, Autilio, C (2021).

Strategies to protect surfactant and enhance its activity

Biomedical Journal. Review. 44(6):654-662.
[doi:10.1016/j.bj.2021.07.011]

Fuso, P, Di Salvatore, M, Santonocito, C, Guarino, D, Autilio, C, Mule, A, Arciuolo, D, Rinninella, A, Mignone, F, Ramundo, M, Di Stefano, B, Orlandi, A, Capoluongo, E, Nicolotti, N, Franceschini, G, Sanchez, AM, Tortora, G, Scambia, G, Barone, C, Cassano, A (2021).

Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients

Journal of Personalized Medicine. Article. 11(8).
[doi:10.3390/jpm11080816]

Cañadas O, García-García A, Prieto MA, Pérez-Gil J (2021).

Polyhydroxyalkanoate Nanoparticles for Pulmonary Drug Delivery: Interaction with Lung Surfactant.

Nanomaterials. Article. 11(6).
[doi:10.3390/nano11061482]

Barriga A, Morán-Lalangui M, Castillo-Sánchez JC, Mingarro I, Pérez-Gil J, García-Álvarez B (2021).

Role of pulmonary surfactant protein Sp-C dimerization on membrane fragmentation: An emergent mechanism involved in lung defense and homeostasis.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1863(6):183572-183572.
[doi:10.1016/j.bbamem.2021.183572]

Castillo-Sánchez JC, Cruz A, Pérez-Gil J (2021).

Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. Article. 703:108850-108850.
[doi:10.1016/j.abb.2021.108850]

Guagliardo R, Herman L, Penders J, Zamborlin A, De Keersmaecker H, Van de Vyver T, Verstraeten S, Merckx P, Mingeot-Leclercq MP, Echaide M, Pérez-Gil J, Stevens MM, De Smedt SC, Raemdonck K (2021).

Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action.

Acs Nano. Article. 15(5):8095-8109.
[doi:10.1021/acsnano.0c04489]

Autilio C, Echaide M, Cruz A, García-Mouton C, Hidalgo A, Da Silva E, De Luca D, Sørli JB, Pérez-Gil J (2021).

Author Correction: Molecular and biophysical mechanisms behind the enhancement of lung surfactant function during controlled therapeutic hypothermia.

SCIENTIFIC REPORTS. Correction. 11(1):9990-9990.
[doi:10.1038/s41598-021-89532-6]

Paget TL, Parkinson-Lawrence EJ, Trim PJ, Autilio C, Panchal MH, Koster G, Echaide M, Snel MF, Postle AD, Morrison JL, Pérez-Gil J, Orgeig S (2021).

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse.

Cells. Article. 10(4).
[doi:10.3390/cells10040849]

De Luca D, Autilio C, Pezza L, Shankar-Aguilera S, Tingay DG, Carnielli VP (2021).

Personalized Medicine for the Management of RDS in Preterm Neonates.

NEONATOLOGY. Review. 118(2):127-138.
[doi:10.1159/000513783]

Schipke, J, Jutte, D, Brandenberger, C, Autilio, C, Perez-Gil, J, Bernhard, W, Ochs, M, Muhlfeld, C (2021).

Dietary Carbohydrates and Fat Induce Distinct Surfactant Alterations in Mice

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Article. 64(3):379-390.
[doi:10.1165/rcmb.2020-0335OC]

De Luca D, Cogo P, Kneyber MC, Biban P, Semple MG, Perez-Gil J, Conti G, Tissieres P, Rimensberger PC (2021).

Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps.

CRITICAL CARE. Review. 25(1):75-75.
[doi:10.1186/s13054-021-03489-6]

Martinez-Calle, M, Parra-Ortiz, E, Cruz, A, Olmeda, B, Perez-Gil, J (2021).

Towards the Molecular Mechanism of Pulmonary Surfactant Protein SP-B: At the Crossroad of Membrane Permeability and Interfacial Lipid Transfer

JOURNAL OF MOLECULAR BIOLOGY. Article. 433(3):166749-166749.
[doi:10.1016/j.jmb.2020.166749]

Garcia-Mouton, C, Hidalgo, A, Arroyo, R, Echaide, M, Cruz, A, Perez-Gil, J (2021).

Pulmonary Surfactant and Drug Delivery: An Interface-Assisted Carrier to Deliver Surfactant Protein SP-D Into the Airways

Frontiers in Bioengineering and Biotechnology. Article. 8:613276-613276.
[doi:10.3389/fbioe.2020.613276]

Autilio, C, Echaide, M, Cruz, A, Mouton, C, Hidalgo, A, Da Silva, E, De Luca, D, Jorid, BS, Perez-Gil, J (2021).

Molecular and biophysical mechanisms behind the enhancement of lung surfactant function during controlled therapeutic hypothermia

SCIENTIFIC REPORTS. Article. 11(1):728-728.
[doi:10.1038/s41598-020-79025-3]

Hidalgo A, Garcia-Mouton C, Autilio C, Carravilla P, Orellana G, Islam MN, Bhattacharya J, Bhattacharya S, Cruz A, Pérez-Gil J (2021).

Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations.

JOURNAL OF CONTROLLED RELEASE. Article. 329:205-222.
[doi:10.1016/j.jconrel.2020.11.042]

Da Silva E, Autilio C, Hougaard KS, Baun A, Cruz A, Perez-Gil J, Sørli JB (2021).

Molecular and biophysical basis for the disruption of lung surfactant function by chemicals

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1863(1):183499-183499.
[doi:10.1016/j.bbamem.2020.183499]

2020

Foligno, S, Loi, B, Pezza, L, Piastra, M, Autilio, C, De Luca, D (2020).

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues.

JOURNAL OF CLINICAL PHARMACOLOGY. Review. 60(12):1561-1572.
[doi:10.1002/jcph.1675]

Yazicioglu, T, Muhlfeld, C, Autilio, C, Huang, CK, Bär C, Dittrich-Breiholz, O, Thum, T, Perez-Gil, J, Schmiedl, A, Brandenberger, C (2020).

Aging impairs alveolar epithelial type II cell function in acute lung injury.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Article. 319(5):755-769.
[doi:10.1152/ajplung.00093.2020]

Testoni G, Olmeda B, Duran J, López-Rodríguez E, Aguilera M, Hernández-Álvarez MI, Prats N, Pérez-Gil J, Guinovart JJ (2020).

Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome

HUMAN MOLECULAR GENETICS. Article. 29(21):3554-3565.
[doi:10.1093/hmg/ddaa249]

Piñeiro-Hermida S, Autilio, C, Martínez, P, Bosch, F, Pérez-Gil, J, Blasco, MA (2020).

Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging.

JOURNAL OF CELL BIOLOGY. Article. 219(10).
[doi:10.1083/jcb.202002120]

Autilio, C, Echaide, M, Dell'Orto, V, Perez-Gil, J, De Luca, D (2020).

Effect of Whole Body Hypothermia on Surfactant Function When Amniotic Fluid is Meconium Stained.

Therapeutic Hypothermia and Temperature Management. Article. 10(3):186-189.
[doi:10.1089/ther.2017.0012]

Autilio, C, Echaide, M, Shankar-Aguilera, S, Bragado, R, Amidani, D, Salomone, F, Perez-Gil, J, De Luca, D (2020).

Surfactant Injury in the Early Phase of Severe Meconium Aspiration Syndrome.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Article. 63(3):327-337.
[doi:10.1165/rcmb.2019-0413OC]

Arroyo, R, Echaide, M, Moreno-Herrero, F, Perez-Gil, J, Kingma, PS (2020).

Functional characterization of the different oligomeric forms of human surfactant protein SP-D.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. Article. 1868(8):140436-140436.
[doi:10.1016/j.bbapap.2020.140436]

Arroyo, R, Echaide, M, Wilmanowski, R, Martin-Gonzalez, A, Batllori, E, Galindo, A, Rosenbaum, JS, Moreno-Herrero, F, Kingma, PS, Perez-Gil, J (2020).

Structure and activity of human surfactant protein D from different natural sources.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Article. 319(1):148-158.
[doi:10.1152/ajplung.00007.2020]

De Luca, D, Shankar-Aguilera, S, Autilio, C, Raschetti, R, Vedovelli, L, Fitting, C, Payre, C, Jeammet, L, Perez-Gil, J, Cogo, PE, Carnielli, VP, Lambeau, G, Touqui, L (2020).

Surfactant-secreted phospholipase A(2) interplay and respiratory outcome in preterm neonates.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Article. 319(1):95-104.
[doi:10.1152/ajplung.00462.2019]

Oeo-Santos, C, López-Rodríguez, JC, García-Mouton, C, San Segundo-Acosta, P, Jurado, A, Moreno-Aguilar, C, García-Alvarez, B, Pérez-Gil, J, Villalba, M, Barderas, R, Cruz, A (2020).

Biophysical and biological impact on the structure and IgE-binding of the interaction of the olive pollen allergen Ole e 7 with lipids.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1862(6):183258-183258.
[doi:10.1016/j.bbamem.2020.183258]

Martinez-Calle, M, Prieto, M, Olmeda, B, Fedorov, A, Loura LMS, Pérez-Gil, J (2020).

Pulmonary surfactant protein SP-B nanorings induce the multilamellar organization of surfactant complexes.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1862(6):183216-183216.
[doi:10.1016/j.bbamem.2020.183216]

Cañadas O, Olmeda, B, Alonso, A, Perez-Gil, J (2020).

Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Review. 21(10).
[doi:10.3390/ijms21103708]

Liekkinen, J, Enkavi, G, Javanainen, M, Olmeda, B, Pérez-Gil, J, Vattulainen, I (2020).

Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex.

JOURNAL OF MOLECULAR BIOLOGY. Article. 432(10):3251-3268.
[doi:10.1016/j.jmb.2020.02.028]

Pablos, JL, Navarro, F, Blanco, FJ, Roman-Ivorra, JA, Alonso, A, Mola, EM, Cantalejo, M, Ercole, L, Rivero, N, Study Investigators (2020).

Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study (vol 37, pg 437, 2019)

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. Correction. 38(3):585-585.

Ruwisch, J, Sehlmeyer, K, Roldan, N, Garcia-Alvarez, B, Perez-Gil, J, Weaver, TE, Ochs, M, Knudsen, L, Lopez-Rodriguez, E (2020).

Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Article. 62(4):466-478.
[doi:10.1165/rcmb.2019-0358OC]

Sørli JB, Låg M, Ekeren, L, Perez-Gil, J, Haug, LS, Da Silva, E, Matrod, MN, Gutzkow, KB, Lindeman, B (2020).

Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells.

TOXICOLOGY IN VITRO. Article. 62:104656-104656.
[doi:10.1016/j.tiv.2019.104656]

Echaide, M, Autilio, C, Lopez-Rodriguez, E, Cruz, A, Perez-Gil, J (2020).

In Vitro Functional and Structural Characterization of A Synthetic Clinical Pulmonary Surfactant with Enhanced Resistance to Inhibition.

SCIENTIFIC REPORTS. Article. 10(1):1385-1385.
[doi:10.1038/s41598-020-58248-4]

2019

Arroyo, R, Khan, MA, Echaide, M, Perez-Gil, J, Palaniyar, N (2019).

SP-D attenuates LPS-induced formation of human neutrophil extracellular traps (NETs), protecting pulmonary surfactant inactivation by NETs.

Communications Biology. Article. 2:470-470.
[doi:10.1038/s42003-019-0662-5]

Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A (2019).

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection.

Immunity. Correction. 51(5):966-967.
[doi:10.1016/j.immuni.2019.11.001]

Garcia-Mouton, C, Hidalgo, A, Cruz, A, Perez-Gil, J (2019).

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. Article. 144:230-243.
[doi:10.1016/j.ejpb.2019.09.020]

Martinez-Calle, M, Alonso, A, Perez-Gil, J, Olmeda, B (2019).

Native supramolecular protein complexes in pulmonary surfactant: Evidences for SP-A/SP-B interactions.

JOURNAL OF PROTEOMICS. Article. 207:103466-103466.
[doi:10.1016/j.jprot.2019.103466]

Guagliardo, R, Merckx, P, Zamborlin, A, De Backer, L, Echaide, M, Perez-Gil, J, De Smedt, SC, Raemdonck, K (2019).

Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA.

Pharmaceutics. Article. 11(9).
[doi:10.3390/pharmaceutics11090431]

Autilio, C, Perez-Gil, J (2019).

Understanding the principle biophysics concepts of pulmonary surfactant in health and disease.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION. Review. 104(4):443-451.
[doi:10.1136/archdischild-2018-315413]

De Corso, E, Anzivino, R, Galli, J, Baroni, S, Di Nardo, W, De Vita, C, Salvati, A, Autilio, C, Settimi, S, Mele, D, Paludetti, G, Mullol, J (2019).

Antileukotrienes improve naso-ocular symptoms and biomarkers in patients with NARES and asthma

Laryngoscope. Article. 129(3):551-557.
[doi:10.1002/lary.27576]

Lopez-Rodriguez, E, Roldan, N, Garcia-Alvarez, B, Perez-Gil, J (2019).

Protein and lipid fingerprinting of native-like membrane complexes by combining TLC and protein electrophoresis[S]

JOURNAL OF LIPID RESEARCH. Article. 60(2):430-435.
[doi:10.1194/jlr.D090639]

2018

Guagliardo, R, Perez-Gil, J, De Smedt, S, Raemdonck, K (2018).

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

JOURNAL OF CONTROLLED RELEASE. Article. 291:116-126.
[doi:10.1016/j.jconrel.2018.10.012]

Madsen, J, Panchal, MH, Mackay, RMA, Echaide, M, Koster, G, Aquino, G, Pelizzi, N, Perez-Gil, J, Salomone, F, Clark, HW, Postle, AD (2018).

Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice

JOURNAL OF LIPID RESEARCH. Article. 59(10):1880-1892.
[doi:10.1194/jlr.M085431]

Lugones, Y, Blanco, O, Lopez-Rodriguez, E, Echaide, M, Cruz, A, Perez-Gil, J (2018).

Inhibition and counterinhibition of Surfacen, a clinical lung surfactant of natural origin

PLOS ONE. Article. 13(9).
[doi:10.1371/journal.pone.0204050]

Merckx, P, De Backer, L, Van Hoecke, L, Guagliardo, R, Echaide, M, Baatsen, P, Olmeda, B, Saelens, X, Perez-Gil, J, De Smedt, SC, Raemdonck, K (2018).

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

ACTA BIOMATERIALIA. Article. 78:236-246.
[doi:10.1016/j.actbio.2018.08.012]

Martinez-Calle, M, Olmeda, B, Dietl, P, Frick, M, Perez-Gil, J (2018).

Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells

FASEB JOURNAL. Article. 32(8):4600-4611.
[doi:10.1096/fj.201701462RR]

Cabre, EJ, Martinez-Calle, M, Prieto, M, Fedorov, A, Olmeda, B, Loura LMS, Perez-Gil, J (2018).

Homo- and hetero-oligomerization of hydrophobic pulmonary surfactant proteins SP-B and SP-C in surfactant phospholipid membranes

JOURNAL OF BIOLOGICAL CHEMISTRY. Article. 293(24):9399-9411.
[doi:10.1074/jbc.RA117.000222]

Autilio, C, Echaide, M, De Luca, D, Perez-Gil, J (2018).

Controlled hypothermia may improve surfactant function in asphyxiated neonates with or without meconium aspiration syndrome

PLOS ONE. Article. 13(2).
[doi:10.1371/journal.pone.0192295]

Castillo-Sanchez, JC, Roldan, N, Garcia-Alvarez, B, Batllori-Badia, E, Galindo, A, Cruz, A, Perez-Gil, J (2018).

Looking for Groundbreaking Structural and Functional Features in the Lung Surfactant System using a Surface-Active Agent Purified from Human Amniotic Fluid

BIOPHYSICAL JOURNAL. Meeting Abstract. 114(3):103-103.
[doi:10.1016/j.bpj.2017.11.605]

2017

Carravilla P, Cruz A, Martin-Ugarte I, Oar-Arteta IR, Torralba J, Apellaniz B, Pérez-Gil J, Requejo-Isidro J, Huarte N, Nieva JL (2017).

Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid; Membranes

BIOPHYSICAL JOURNAL. Article. 113(6):1301-1310.
[doi:10.1016/j.bpj.2017.06.061]

Hidalgo A, Cruz A, Perez-Gil J (2017).

Pulmonary surfactant and nanocarriers: Toxicity versus combined; nanomedical applications

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1859(9):1740-1748.
[doi:10.1016/j.bbamem.2017.04.019]

Echaide M, Autilio C, Arroyo R, Perez-Gil J (2017).

Restoring pulmonary surfactant membranes and films at the respiratory; surface

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1859(9):1725-1739.
[doi:10.1016/j.bbamem.2017.03.015]

Roldan, N, Perez-Gil, J, Morrow, MR, Garcia-Alvarez, B (2017).

Divide & Conquer: Surfactant Protein SP-C and Cholesterol Modulate Phase; Segregation in Lung Surfactant

BIOPHYSICAL JOURNAL. Article. 113(4):847-859.
[doi:10.1016/j.bpj.2017.06.059]

Hidalgo A, Salomone F, Fresno N, Orellana G, Cruz A, Perez-Gil J (2017).

Efficient Interfacially Driven Vehiculization of Corticosteroids by; Pulmonary Surfactant

Langmuir. Article. 33(32):7929-7939.
[doi:10.1021/acs.langmuir.7b01177]

Lemke, A, Castillo-Sanchez, JC, Prodinger, F, Ceranic, A, Hennerbichler-Lugscheider, S, Perez-Gil, J, Redl, H, Wolbank, S (2017).

Human amniotic membrane as newly identified source of amniotic fluid; pulmonary surfactant

SCIENTIFIC REPORTS. Article. 7.
[doi:10.1038/s41598-017-06402-w]

Autilio C, Echaide M, Benachi A, Marfaing-Koka A, Capoluongo ED, Pérez-Gil J, De Luca D (2017).

A Noninvasive Surfactant Adsorption Test Predicting the Need for; Surfactant Therapy in Preterm Infants Treated with Continuous Positive; Airway Pressure

JOURNAL OF PEDIATRICS. Article. 182:66-73.
[doi:10.1016/j.jpeds.2016.11.057]

Olmeda B, Martínez-Calle M, Pérez-Gil J (2017).

Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis,; extracellular conversions, recycling

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER. Article. 209:78-92.
[doi:10.1016/j.aanat.2016.09.008]

2016

Autilio, C., Echaide, M., Letamendia, E., Wittver, A., Benachi, A., Capoluongo, E. D., Perez-Gil, J., De Luca, D. (2016).

SURFACTANT ADSORPTION TEST AS SCREENING FOR SURFACTANT NEED IN; CPAP-TREATED PRETERM NEONATES.

EUROPEAN JOURNAL OF PEDIATRICS. Meeting Abstract. 175(11):1480-1480.

Lopez-Rodriguez, Juan C., Barderas, Rodrigo, Echaide, Mercedes, Perez-Gil, Jesus, Villalba, Mayte, Batanero, Eva, Cruz, Antonio (2016).

Surface Activity as a Crucial Factor of the Biological Actions of Ole e 1, the Main Aeroallergen of Olive Tree (Olea europaea) Pollen

Langmuir. Article. 32(42):11055-11062.
[doi:10.1021/acs.langmuir.6b02831]

Roldan N, Nyholm TK, Slotte JP, Pérez-Gil J, García-Álvarez B (2016).

Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics

BIOPHYSICAL JOURNAL. Article. 111(8):1703-1713.
[doi:10.1016/j.bpj.2016.09.016]

Huarte N, Carravilla P, Cruz A, Lorizate M, Nieto-Garai JA, Kräusslich HG, Pérez-Gil J, Requejo-Isidro J, Nieva JL (2016).

Functional organization of the HIV lipid envelope

SCIENTIFIC REPORTS. Article. 6:34190-34190.
[doi:10.1038/srep34190]

Lopez-Rodriguez E, Pascual A, Arroyo R, Floros J, Perez-Gil J (2016).

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films

BIOPHYSICAL JOURNAL. Article. 111(3):524-536.
[doi:10.1016/j.bpj.2016.06.025]

Hobi N, Giolai M, Olmeda B, Miklavc P, Felder E, Walther P, Dietl P, Frick M, Pérez-Gil J, Haller T (2016).

A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. Article. 1863(8):2124-2134.
[doi:10.1016/j.bbamcr.2016.04.028]

Lopez-Rodriguez, E., Laukamp, C., Hidalgo, A., Cruz, A., Perez-Gil, J., Ochs, M., Knudsen, L. (2016).

Using Pulmonary Surfactant As Pirfenidone Vehicle To Target Lung Epithelium In Bleomycin-Induced Lung Fibrosis

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Meeting Abstract. 193.

2015

De Backer, Lynn, Cerrada, Alejandro, Perez-Gil, Jesus, De Smedt, Stefaan C., Raemdonck, Koen (2015).

Bio-inspired materials in drug delivery: Exploring the role of pulmonary surfactant in siRNA inhalation therapy

JOURNAL OF CONTROLLED RELEASE. Article. 220(B):642-650.
[doi:10.1016/j.jconrel.2015.09.004]

Raesch SS, Tenzer S, Storck W, Rurainski A, Selzer D, Ruge CA, Perez-Gil J, Schaefer UF, Lehr CM (2015).

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

Acs Nano. Article. 9(12):11872-11885.
[doi:10.1021/acsnano.5b04215]

Cerrada A, Haller T, Cruz A, Pérez-Gil J (2015).

Pneumocytes Assemble Lung Surfactant as Highly Packed/Dehydrated States with Optimal Surface Activity

BIOPHYSICAL JOURNAL. Article. 109(11):2295-2306.
[doi:10.1016/j.bpj.2015.10.022]

Olmeda, Barbara, Garcia-Alvarez, Begona, Gomez, Manuel J., Martinez-Calle, Marta, Cruz, Antonio, Perez-Gil, Jesus (2015).

A model for the structure and mechanism of action of pulmonary surfactant protein B

FASEB JOURNAL. Article. 29(10):4236-4247.
[doi:10.1096/fj.15-273458]

Hidalgo, Alberto, Cruz, Antonio, Perez-Gil, Jesus (2015).

Barrier or carrier? Pulmonary surfactant and drug delivery

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. Article. 95(A):117-127.
[doi:10.1016/j.ejpb.2015.02.014]

Perez-Gil, Jesus, Monroy, Francisco (Paco) (2015).

Surfing the continuous and walking amongst molecules to unravel the mechanical properties of biomembranes

CHEMISTRY AND PHYSICS OF LIPIDS. Editorial Material. 185(SI):1-2.
[doi:10.1016/j.chemphyslip.2014.12.002]

Roldan, Nuria, Goormaghtigh, Erik, Perez-Gil, Jesus, Garcia-Alvarez, Begona (2015).

Palmitoylation as a key factor to modulate SP-C-lipid interactions in lung surfactant membrane multilayers

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. Article. 1848(1):184-191.
[doi:10.1016/j.bbamem.2014.10.009]