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Immuno-oncology and Immunotherapy

Publications

2025

Gómez-Rosel, M, Rubio-Pérez, L, Zagorac, I, Domínguez-Alonso, C, Díez-Alonso, L, Hangiu, O, Navarro, R, Torres-Ruíz, R, Rodríguez-Perales, S, Blanco, FJ, Compte, M, Alvarez-Vallina, L, Blanco, B (2025).

Simultaneous secretion of a PD-L1 x 4-1BB bispecific antibody improves antileukemic efficacy of STAb-T cells secreting a CD19-specific T-cell engager

OncoImmunology. Article. 14(1).
[doi:10.1080/2162402X.2025.2570224]
Velasco-Sidro, M, Arroyo-Ródenas, J, Díez-Alonso, L, Ramírez-Fernández, A, alvarez-Vallina, L (2025).

Dual-targeted STAb-T cells secreting BCMA and CD19 T cell engagers for improved control of haematological cancers

OncoImmunology. Article. 14(1).
[doi:10.1080/2162402X.2024.2444701]
Zagorac, I, Ramírez-Fernández, A, Tapia-Galisteo, A, Rubio-Pérez, L, Gomez-Rosel, M, Grau, M, Rodríguez-Peralto, JL, Alvarez-Vallina, L, Blanco, B (2025).

mRNA-engineered T lymphocytes secreting bispecific T cell engagers with therapeutic potential in solid tumors

Frontiers in Immunology. Article. 16.
[doi:10.3389/fimmu.2025.1684655]
Narbona, J, Lázaro-Gorines, R, Gutiérrez-Carmona, A, López-Rodríguez, JC, Villalba, M, Lacadena, J (2025).

An Innovative Immunotoxin Design Against Allergy Based on the IL-33 Cytokine and the Ribotoxin a-Sarcin

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 26(19).
[doi:10.3390/ijms26199827]
Segura-Tudela, A, Nieto-López, C, Bermejo-Olivera, FJ, Andara, LA, Arroyo-Ródenas, J, Dueñas-Prieto, L, Alfocea-Molina, A, Paz-Artal, E, Pleguezuelo, D, Cabrera-Marante, O, Allende, LM (2025).

Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity

JOURNAL OF CLINICAL IMMUNOLOGY. Article. 45(1).
[doi:10.1007/s10875-025-01935-6]
Chivite-Lacaba, M, Justo, I, Utrero-Rico, A, Caso, O, González-Cuadrado, C, Del Rey, MJ, Laguna-Goya, R, Arroyo-Ródenas, J, Alfocea-Molina, A, Ruigómez-Martín, CC, Serrano, M, Pascual-Palacios, L, Mancebo, ME, Paz-Artal, E (2025).

Delineation of monocytic and early-stage myeloid-derived suppressor cells in the peripheral blood of patients with hepatocarcinoma

INTERNATIONAL JOURNAL OF CANCER. Article. 156(12):2416-2428.
[doi:10.1002/ijc.35390]
Pilati, D, Agyei, EK, Elkhashab, M, Fuchs, E, Nielsen, IH, Bjerg, TW, Anthi, AK, Jiméenez-Reinoso, A, Iversen, MB, Pohl, L, Narita, R, Frago, S, Jakobsen, MR, Andersen, JT, Degn, SE, Paludan, SR, Alvarez-Vallina, L, Howard, KA (2025).

Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction

JOURNAL OF BIOLOGICAL CHEMISTRY. Article. 301(6).
[doi:10.1016/j.jbc.2025.108508]
Falgàs, A, Lázaro-Gorines, R, Zanetti, SR, Rubio-Pérez, L, Martínez-Moreno, A, Vinyoles, M, Guerrero-Murillo, M, Fernández-Fuentes, N, Roca-Ho, H, Tirado, N, Panisello, C, Velasco-Hernandez, T, Mayado, A, Pérez-Pons, A, Genescà, E, Ribera, JM, Ribera, J, Camos, M, Ramírez-Orellana, M, Anguita, E, Ballerini, P, Fuster, JL, Juan, ME, González-Navarro, EA, Locatelli, F, Stam, RW, Querol, S, Velasco, P, Ortiz-Maldonado, V, Martínez-Cibrián, N, Delgado, J, Orfao, A, Alvarez-Vallina, L, Bueno, C, Menéndez, P (2025).

A TIM-3-Fc decoy secreted by engineered T cells improves CD19 CAR T-cell therapy in B-cell acute lymphoblastic leukemia

BLOOD. Article. 145(22):2599-2613.
[doi:10.1182/blood.2024025440]
Arroyo-Ródenas, J, Falgas, A, Díez-Alonso, L, Martinez-Moreno, A, Roca-Ho, H, Gil-Etayo, FJ, Pérez-Pons, A, Aguilar-Sopeña, O, Velasco-Sidro, M, Gómez-Rosel, M, Jiménez-Matías, B, Muñoz-Sánchez, G, Pacheco, Y, Bravo-Martín, C, Ramírez-Fernández, A, Jiménez-Reinoso, A, González-Navarro, EA, Juan, ME, Orfao, A, Blanco, B, Roda-Navarro, P, Bueno, C, Menéndez, P, Alvarez-Vallina, L (2025).

CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukemia progression

Journal for ImmunoTherapy of Cancer. Article. 13(4).
[doi:10.1136/jitc-2024-009048]
Hangiu, O, Navarro, R, Frago, S, Rubio-Pérez, L, Tapia-Galisteo, A, Díez-Alonso, L, Gómez-Rosel, M, Silva-Pilipich, N, Vanrell, L, Smerdou, C, Howard, KA, Sanz, L, Alvarez-Vallina, L, Compte, M (2025).

Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation

Frontiers in Immunology. Article. 15.
[doi:10.3389/fimmu.2024.1494206]

2024

Jiménez-Reinoso, A, Molero-Abraham, M, Cirauqui, C, Blanco, B, Garrido-Martin, EM, Nehme-Alvarez, D, Domínguez-Alonso, C, Ramírez-Fernández, A, Díez-Alonso, L, Nuñez-Buiza, A, González-Murillo, A, Tobes, R, Pareja, E, Ramírez-Orellana, M, Rodriguez-Peralto, JL, Ferrer, I, Zugazagoitia, J, Paz-Ares, L, Alvarez-Vallina, L (2024).

CD4+ tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts

OncoImmunology. Article. 13(1):2392897-2392897.
[doi:10.1080/2162402X.2024.2392897]
Tapia-Galisteo, A, Sánchez-Rodríguez, I, Narbona, J, Iglesias-Hernández, P, Aragón-García, S, Jiménez-Reinoso, A, Compte, M, Khan, S, Tsuda, T, Chames, P, Lacadena, J, Alvarez-Vallina, L, Sanz, L (2024).

Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-ß and PD-L1 enhances antitumor responses

OncoImmunology. Article. 13(1):2338558-2338558.
[doi:10.1080/2162402X.2024.2338558]
Navarro, R, Frago, S, Hangiu, O, Erce-Llamazares, A, Lázaro-Gorines, R, Morcillo, MA, Rodriguez-Peralto, JL, Sanz, L, Compte, M, Alvarez-Vallina, L (2024).

Pharmacokinetics and safety of LEAD-452, an EGFR-specific 4-1BB-agon-istic trimerbody in non-human primates

TOXICOLOGY AND APPLIED PHARMACOLOGY. Article. 487:116961-116961.
[doi:10.1016/j.taap.2024.116961]
Rubio-Pérez, L, Frago, S, Compte, M, Navarro, R, Harwood, SL, Lázaro-Gorines, R, Gómez-Rosel, M, Hangiu, O, Silva-Pilipich, N, Vanrell, L, Smerdou, C, Alvarez-Vallina, L (2024).

Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity

Antibodies. Article. 13(2).
[doi:10.3390/antib13020034]
Martín-Antonio, B, Blanco, B, González-Murillo, A, Hidalgo, L, Minguillón, J, Pérez-Chacon, G (2024).

Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations

Frontiers in Immunology. Article. 15.
[doi:10.3389/fimmu.2024.1386856]
Segura-Tudela A, López-Nevado M, Nieto-López C, García-Jiménez S, Díaz-Madroñero MJ, Delgado Á, Cabrera-Marante O, Pleguezuelo D, Morales P, Paz-Artal E, Gil-Niño J, Marco FM, Serrano C, González-Granado LI, Quesada-Espinosa JF, Allende LM (2024).

Enrichment of Immune Dysregulation Disorders in Adult Patients with Human Inborn Errors of Immunity.

JOURNAL OF CLINICAL IMMUNOLOGY. Article. 44(3):61-61.
[doi:10.1007/s10875-024-01664-2]
Díez-Alonso, L, Falgas, A, Arroyo-Ródenas, J, Romencín, PA, Martínez, A, Gomez-Rosel, M, Blanco, B, Jiménez-Reinoso, A, Mayado, A, Perez-Pons, A, Aguilar-Sopeña, O, Ramirez-Fernández, A, Segura-Tudela, A, Pérez-Amill, L, Tapia-Galisteo, A, Domínguez-Alonso, C, Rubio-Peréz, L, Jara, M, Solé, F, Hangiu, O, Almagro, L, Albitre, A, Penela, P, Sanz, L, Anguita, E, Valeri, A, García-Ortiz, A, Río, P, Juan, ME, Martínez-López, J, Roda-Navarro, P, Martín-Antonio, B, Orfao, A, Menéndez, P, Bueno, C, alvarez-Vallina, L (2024).

Engineered T cells secreting anti-BCMA T cell engagers control multiple myeloma and promote immune memory in vivo

Science Translational Medicine. Article. 16(734).
[doi:10.1126/scitranslmed.adg7962]

2023

Antunes, A, Alvarez-Vallina, L, Bertoglio, F, Bouquin, N, Cornen, S, Duffieux, F, Ferré, P, Gillet, R, Jorgensen, C, Leick, MB, Maillère, B, Negre, H, Pelegrin, M, Poirier, N, Reusch, D, Robert, B, Serre, G, Vicari, A, Villalba, M, Volpers, C, Vuddamalay, G, Watier, H, Wurch, T, Zabeau, L, Zielonka, S, Zhang, BL, Beck, A, Martineau, P (2023).

10th antibody industrial symposium: new developments in antibody and adoptive cell therapies

mAbs. Article. 15(1).
[doi:10.1080/19420862.2023.2211692]
Rubio-Pérez, L, Lázaro-Gorines, R, Harwood, SL, Compte, M, Navarro, R, Tapia-Galisteo, A, Bonet, J, Blanco, B, Lykkemark, S, Ramírez-Fernández, A, Ferreras-Gutiérrez, M, Domínguez-Alonso, C, Díez-Alonso, L, Segura-Tudela, A, Hangiu, O, Erce-Llamazares, A, Blanco, FJ, Santos, C, Rodríguez-Peralto, JL, Sanz, L, Alvarez-Vallina, L (2023).

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response

OncoImmunology. Article. 12(1).
[doi:10.1080/2162402X.2023.2205336]
Lázaro-Gorines, R, Pérez, P, Heras-Murillo, I, Adán-Barrientos, I, Albericio, G, Astorgano, D, Flores, S, Luczkowiak, J, Labiod, N, Harwood, SL, Segura-Tudela, A, Rubio-Pérez, L, Nugraha, Y, Shang, XR, Li, YX, Alfonso, C, Adipietro, KA, Abeyawardhane, DL, Navarro, R, Compte, M, Yu, WB, Mackerell, AD Jr, Sanz, L, Weber, DJ, Blanco, FJ, Esteban, M, Pozharski, E, Godoy-Ruiz, R, Muñoz, IG, Delgado, R, Sancho, D, Garcia-Arriaza, J, Alvarez-Vallina, L (2023).

Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2

Advanced Science. Article. 10(34).
[doi:10.1002/advs.202304818]
Tapia-Galisteo, A, Alvarez-Vallina, L, Sanz, L (2023).

Bi- and trispecific immune cell engagers for immunotherapy of hematological malignancies

Journal of Hematology & Oncology. Review. 16(1).
[doi:10.1186/s13045-023-01482-w]
Tapia-Galisteo, A, Compte, M, alvarez-Vallina, L, Sanz, L (2023).

When three is not a crowd: trispecific antibodies for enhanced cancer immunotherapy.

Theranostics. Review. 13(3):1028-1041.
[doi:10.7150/thno.81494]
Lopez-Nevado, M, Ortiz-Martin, J, Serrano, C, Perez-Saez, MA, Lopez-Lorenzo, JL, Gil-Etayo, FJ, Rodriguez-Frias, E, Cabrera-Marante, O, Morales-Perez, P, Rodriguez-Pinilla, MS, Manso, R, Salgado-Sanchez, RN, Cerda-Montagud, A, Quesada-Espinosa, JF, Gomez-Rodriguez, MJ, Paz-Artal, E, Munoz-Calleja, C, Arranz-Saez, R, Allende, LM (2023).

Novel Germline TET2 Mutations in Two Unrelated Patients with Autoimmune Lymphoproliferative Syndrome-Like Phenotype and Hematologic Malignancy

JOURNAL OF CLINICAL IMMUNOLOGY. Article. 43(1):165-180.
[doi:10.1007/s10875-022-01361-y]

2022

Carrasco-Padilla, C, Hernaiz-Esteban, A, alvarez-Vallina, L, Aguilar-Sopena, O, Roda-Navarro, P (2022).

Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy.

Pharmaceutics. Review. 15(1).
[doi:10.3390/pharmaceutics15010132]
Jimenez-Reinoso, A, Tirado, N, Martinez-Moreno, A, Diaz, VM, Garcia-Peydro, M, Hangiu, O, Diez-Alonso, L, Albitre, A, Penela, P, Toribio, ML, Menendez, P, Alvarez-Vallina, L, Martinez, DS (2022).

Efficient preclinical treatment of cortical T cell acute lymphoblastic leukemia with T lymphocytes secreting anti-CD1a T cell engagers

Journal for ImmunoTherapy of Cancer. Article. 10(12).
[doi:10.1136/jitc-2022-005333]
Marin, AV, Jimenez-Reinoso, A, Mazariegos, MS, Roman-Ortiz, E, Regueiro, JR (2022).

T-cell receptor signaling in Schimke immuno-osseous dysplasia is SMARCAL1-independent.

Frontiers in Immunology. Article. 13:979722-979722.
[doi:10.3389/fimmu.2022.979722]
Hangiu, O, Compte, M, Dinesen, A, Navarro, R, Tapia-Galisteo, A, Mandrup, OA, Erce-Llamazares, A, Lázaro-Gorines, R, Nehme-Alvarez, D, Domínguez-Alonso, C, Harwood, SL, Alfonso, C, Blanco, B, Rubio-Pérez, L, Jiménez-Reinoso, A, Díez-Alonso, L, Blanco, FJ, Sanz, L, Howard, KA, Alvarez-Vallina, L (2022).

Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity

iScience. Article. 25(9):104958-104958.
[doi:10.1016/j.isci.2022.104958]
Blanco B, Ramírez-Fernández Á, Bueno C, Argemí-Muntadas L, Fuentes P, Aguilar-Sopeña Ó, Gutierrez-Agüera F, Zanetti SR, Tapia-Galisteo A, Díez-Alonso L, Segura-Tudela A, Castellà M, Marzal B, Betriu S, Harwood SL, Compte M, Lykkemark S, Erce-Llamazares A, Rubio-Pérez L, Jiménez-Reinoso A, Domínguez-Alonso C, Neves M, Morales P, Paz-Artal E, Guedan S, Sanz L, Toribio ML, Roda-Navarro P, Juan M, Menéndez P, Álvarez-Vallina L (2022).

Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers.

Cancer Immunology Research. Article. 10(4):498-511.
[doi:10.1158/2326-6066.CIR-21-0853]
Ramírez-Fernández Á, Aguilar-Sopeña Ó, Díez-Alonso L, Segura-Tudela A, Domínguez-Alonso C, Roda-Navarro P, Álvarez-Vallina L, Blanco B (2022).

Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies.

OncoImmunology. Article. 11(1):2054106-2054106.
[doi:10.1080/2162402X.2022.2054106]
Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L (2022).

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.

OncoImmunology. Article. 11(1):2034355-2034355.
[doi:10.1080/2162402X.2022.2034355]
Paredes-Ruiz D, Gómez-Cuervo C, Gómez-Martín C, Sánchez-Guerrero Á, González-Olmedo J, López-López F, Bover-Larroya M, Yarza-Barrio R, Jara-Casas DD, Castelo-Laureiro A, Revilla-Ostolaza Y, Paz-Ares L, Lumbreras-Bermejo C, Díaz-Pedroche C (2022).

Incidence of venous thromboembolism in patients with non-hematological cancer admitted for COVID-19 at a third-level hospital in Madrid

JOURNAL OF THROMBOSIS AND THROMBOLYSIS. Article. 53(2):1-8.
[doi:10.1007/s11239-021-02448-w]
Gil-Etayo FJ, Garcinuño S, Utrero-Rico A, Cabrera-Marante O, Arroyo-Sanchez D, Mancebo E, Pleguezuelo DE, Rodríguez-Frías E, Allende LM, Morales-Pérez P, Castro-Panete MJ, Lalueza A, Lumbreras C, Paz-Artal E, Serrano A (2022).

An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution.

Biomedicines. Article. 10(2).
[doi:10.3390/biomedicines10020296]
Compte, M, Sanz, L, Alvarez-Vallina, L (2022).

Applications of trimerbodies in cancer immunotherapy

International Review of Cell and Molecular Biology. Article. 369:71-87.
[doi:10.1016/bs.ircmb.2022.03.008]

2021

Sanz, L, Alvarez-Vallina, L (2021).

Engineered mRNA and the Rise of Next-Generation Antibodies

Antibodies. Article. 10(4).
[doi:10.3390/antib10040037]
Blanco B, Domínguez-Alonso C, Alvarez-Vallina L (2021).

Bispecific Immunomodulatory Antibodies for Cancer Immunotherapy.

CLINICAL CANCER RESEARCH. Review. 27(20):5457-5464.
[doi:10.1158/1078-0432.CCR-20-3770]
Garcillan, B, Fuentes, P, Marin, AV, Megino, RF, Chacon-Arguedas, D, Mazariegos, MS, Jimenez-Reinoso, A, Munoz-Ruiz, M, Laborda, RG, Cardenas, PP, Fernandez-Malave, E, Toribio, ML, Regueiro, JR (2021).

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCR alpha beta Complex

Frontiers in Cell and Developmental Biology. Article. 9.
[doi:10.3389/fcell.2021.608490]
Yarza R, Bover M, Agulló-Ortuño MT, Iglesias-Docampo LC (2021).

Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. Review. 40(1):202-202.
[doi:10.1186/s13046-021-02010-9]
Rousso-Noori L, Mastandrea I, Talmor S, Waks T, Globerson Levin A, Haugas M, Teesalu T, Alvarez-Vallina L, Eshhar Z, Friedmann-Morvinski D (2021).

P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas.

Nature Communications. Article. 12(1):3615-3615.
[doi:10.1038/s41467-021-23817-2]
Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme-Álvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Munoz, IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L (2021).

An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity

CLINICAL CANCER RESEARCH. Article. 27(11):3167-3177.
[doi:10.1158/1078-0432.CCR-20-4625]
López-Nevado M, Docampo-Cordeiro J, Ramos JT, Rodríguez-Pena R, Gil-López C, Sánchez-Ramón S, Gil-Herrera J, Díaz-Madroñero MJ, Delgado-Martín MA, Morales-Pérez P, Paz-Artal E, Magerus A, Rieux-Laucat F, Allende LM (2021).

Next Generation Sequencing for Detecting Somatic FAS Mutations in Patients With Autoimmune Lymphoproliferative Syndrome.

Frontiers in Immunology. Article. 12:656356-656356.
[doi:10.3389/fimmu.2021.656356]
Arteche-Lopez, A, Rodriguez, MJG, Calvin, MTS, Quesada-Espinosa, JF, Rosales, JML, Milla, CP, Gomez-Manjon, I, Mayoral, IH, de la Fuente, RP, de Bustamante, AD, Darnaude, MT, Gil-Fournier, B, Leon, SR, Gomez, PR, Tomillo, OS, Rufian, AJ, Cano, MIA, Alonso, RV, Morales-Perez, P, Segura-Tudela, A, Camacho, A, Nunez, N, Simon, R, Moreno-Garcia, M, Alvarez-Mora, MI (2021).

Towards a Change in the Diagnostic Algorithm of Autism Spectrum Disorders: Evidence Supporting Whole Exome Sequencing as a First-Tier Test

Genes. Article. 12(4).
[doi:10.3390/genes12040560]
Mandrup OA, Ong SC, Lykkemark S, Dinesen A, Rudnik-Jansen I, Dagnæs-Hansen NF, Andersen JT, Alvarez-Vallina L, Howard KA (2021).

Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.

Communications Biology. Article. 4(1):310-310.
[doi:10.1038/s42003-021-01790-2]
Martín-Soberón MC, Ruiz S, De Velasco G, Yarza R, Carretero A, Castellano D, Sepúlveda-Sánchez JM (2021).

Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAF(V600E) mutation treated with dabrafenib-trametinib: a case report.

Journal of Medical Case Reports. Article. 15(1):109-109.
[doi:10.1186/s13256-020-02581-9]
Jiménez-Reinoso A, Nehme-Álvarez D, Domínguez-Alonso C, Álvarez-Vallina L (2021).

Synthetic TILs: Engineered Tumor-Infiltrating Lymphocytes With Improved Therapeutic Potential.

Frontiers in Oncology. Review. 10:593848-593848.
[doi:10.3389/fonc.2020.593848]
Compte M, Harwood SL, Martínez-Torrecuadrada J, Perez-Chacon G, González-García P, Tapia-Galisteo A, Van Bergen En Henegouwen PMP, Sánchez A, Fabregat I, Sanz L, Zapata JM, Alvarez-Vallina L (2021).

Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR.

Frontiers in Immunology. Article. 11:614363-614363.
[doi:10.3389/fimmu.2020.614363]

2020

Navarro, R, Tapia-Galisteo, A, Martín-García, L, Tarín, C, Corbacho, C, Gómez-López, G, Sánchez-Tirado, E, Campuzano, S, González-Cortés, A, Yáñez-Sedeño P, Compte, M, Alvarez-Vallina, L, Sanz, L (2020).

TGF-ß-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.

Molecular Oncology. Article. 14(10):2609-2628.
[doi:10.1002/1878-0261.12779]
Laguna-Goya, R, Utrero-Rico, A, Talayero, P, Lasa-Lazaro, M, Ramirez-Fernandez, A, Naranjo, L, Segura-Tudela, A, Cabrera-Marante, O, Rodriguez de Frias E, Garcia-Garcia, R, Fernández-Ruiz, M, Aguado, JM, Martinez-Lopez, J, Lopez, EA, Catalan, M, Serrano, A, Paz-Artal, E (2020).

IL-6-based mortality risk model for hospitalized patients with COVID-19.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Article. 146(4):799.
[doi:10.1016/j.jaci.2020.07.009]
Tolosa, P, Sanchez-Torre, A, de Cabo, HB, Sanchez-Bayona, R, Herrera, M, Yarza, R, Lema, L, Manso, L, Ciruelos, E (2020).

Impact of CDK 4/6i withdrawal or dose adjustment on COVID-19 incidence in HR+/HER2-mBC patients during the pandemic.

CLINICAL CANCER RESEARCH. Meeting Abstract. 26(18).
Yarza, R, Bover, M, Paredes, D, López-López, F, Jara-Casas, D, Castelo-Loureiro, A, Baena, J, Mazarico, JM, Folgueira, MD, Meléndez-Carmo, MA, Reyes, A, Lumbreras, C, Paz-Ares, L, Díaz-Pedroche, C, Gómez-Martín, C (2020).

SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death.

EUROPEAN JOURNAL OF CANCER. Article. 135:242-250.
[doi:10.1016/j.ejca.2020.06.001]
Cabrera-Marante, O, Rodríguez de Frías E, Pleguezuelo, DE, Allende, LM, Serrano, A, Laguna-Goya, R, Mancebo, ME, Talayero, P, Alvarez-Vallina, L, Morales, P, Castro-Panete, MJ, Paz-Artal, E (2020).

Perforin gene variant A91V in young patients with severe COVID-19.

HAEMATOLOGICA. Letter. 105(12):2844-2846.
[doi:10.3324/haematol.2020.260307]
de Cossio, S, Labrador, B, Yarza, R, Corbella, L, Fernandez-Ruiz, M (2020).

Oesophageal ulcer: An uncommon presentation of tuberculous lymphadenitis mimicking an oesophageal carcinoma.

Gastroenterologia y Hepatologia. Letter. 43(3):133-134.
[doi:10.1016/j.gastrohep.2019.10.002]
Roda-Navarro, P, Alvarez-Vallina, L (2020).

Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy.

Frontiers in Cell and Developmental Biology. Article. 7:370-370.
[doi:10.3389/fcell.2019.00370]
Bover, M, Yarza, R, Docampo, LI (2020).

Four-Year Lasting Sustained Complete Response After Nivolumab in a Patient With Non-Small-Cell Lung Cancer and Confirmed Leptomeningeal Carcinomatosis: Changing the Paradigm.

Clinical Lung Cancer. Article. 21(1):1-5.
[doi:10.1016/j.cllc.2019.07.012]
Blanco, B, Ramírez-Fernández, A, Alvarez-Vallina, L (2020).

Engineering Immune Cells for in vivo Secretion of Tumor-Specific T Cell-Redirecting Bispecific Antibodies.

Frontiers in Immunology. Review. 11:1792-1792.
[doi:10.3389/fimmu.2020.01792]

2019

Soldevilla, B, Carretero-Puche, C, Gomez-Lopez, G, Al-Shahrour, F, Riesco, MC, Gil-Calderon, B, Alvarez-Vallina, L, Espinosa-Olarte, P, Gomez-Esteves, G, Rubio-Cuesta, B, Sarmentero, J, La Salvia, A, Garcia-Carbonero, R (2019).

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications.

EUROPEAN JOURNAL OF CANCER. Article. 123:118-129.
[doi:10.1016/j.ejca.2019.09.008]
Lopez-Gomez, V, Yarza, R, Munoz-Gonzalez, H, Revilta, E, Enrech, S, Gonzalez-Valle, O, Tolosa, P, Ciruelos, E (2019).

Ribociclib-Related Stevens-Johnson Syndrome: Oncologic Awareness, Case Report, and Literature Review

Journal of Breast Cancer. Review. 22(4):661-666.
[doi:10.4048/jbc.2019.22.e44]
Lazaro-Gorines, R, Ruiz-de-la-Herran, J, Navarro, R, Sanz, L, Alvarez-Vallina, L, Martinez-del-Pozo, A, Gavilanes, JG, Lacadena, J (2019).

A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts.

Scientific Reports. Article. 9(1):11680-11680.
[doi:10.1038/s41598-019-48285-z]
Mikkelsen, K, Harwood, SL, Compte, M, Merino, N, Mølgaard K, Lykkemark, S, Alvarez-Mendez, A, Blanco, FJ, Alvarez-Vallina, L (2019).

Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies.

Frontiers in Immunology. Article. 10:1791-1791.
[doi:10.3389/fimmu.2019.01791]
Rios, X, Compte, M, Gomez-Vallejo, V, Cossio, U, Baz, Z, Morcillo, MA, Ramos-Cabrer, P, Alvarez-Vallina, L, Llop, J (2019).

Immuno-PET Imaging and Pharmacokinetics of an Anti-CEA scFv-based Trimerbody and Its Monomeric Counterpart in Human Gastric Carcinoma-Bearing Mice.

MOLECULAR PHARMACEUTICS. Article. 16(3):1025-1035.
[doi:10.1021/acs.molpharmaceut.8b01006]
Blanco, B, Compte, M, Lykkemark, S, Sanz, L, Alvarez-Vallina, L (2019).

T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies

TRENDS IN IMMUNOLOGY. Review. 40(3):243-257.
[doi:10.1016/j.it.2019.01.008]

2018

Compte, M, Harwood, SL, Munoz, IG, Navarro, R, Zonca, M, Perez-Chacon, G, Erce-Llamazares, A, Merino, N, Tapia-Galisteo, A, Cuesta, AM, Mikkelsen, K, Caleiras, E, Nunez-Prado, N, Aznar, MA, Lykkemark, S, Martinez-Torrecuadrada, J, Melero, I, Blanco, FJ, Bernardino de la Serna J, Zapata, JM, Sanz, L, Alvarez-Vallina, L (2018).

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Nature Communications. Article. 9(1):4809-4809.
[doi:10.1038/s41467-018-07195-w]

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