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Tumor Microenvironment and Immunotherapy

Publications

2025

del Rey-Vergara, R, Galindo-Campos, MA, Rocha, P, Carpes, M, Martínez, C, Masfarré, L, Menéndez, S, Quimis, F, Rossell, A, Iñañez, A, Pérez-Buira, S, Rojo, F, Gimeno, R, Isla, D, Zugazagoitia, J, Blanco, CM, García-Campelo, R, Moreno-Vega, A, León-Mateos, L, Mellén, AC, Park, KS, Heeke, S, Heymach, JV, Taus, A, Paz-Ares, L, Rovira, A, Arriola, E (2025).

MET pathway inhibition increases chemo-immunotherapy efficacy in small cell lung cancer

CELL REPORTS MEDICINE. Article. 6(7).
[doi:10.1016/j.xcrm.2025.102194]
Cirauqui, C, Ojeda, L, Otano, I, Pazos, I, Santos, A, Garrido-Martín, EM, Yagüe, P, Ramos-Paradas, J, Molina-Pinelo, S, Roncador, G, Solórzano, JL, Muñoz, MT, Cozar, P, Plaza, P, Suárez, R, Jiménez, M, Moreno, R, Rosado, A, Gámez, P, García-Luján, R, Zugazagoitia, J, Sweet-Cordero, EA, Barbacid, M, Carnero, A, Ferrer, I, Paz-Ares, L (2025).

Interleukin-11 promotes lung adenocarcinoma tumourigenesis and immune evasion

Clinical and Translational Medicine. Article. 15(7).
[doi:10.1002/ctm2.70374]
Bote-de Cabo H, Siringo M, Conde E, Hernández S, López-Ríos F, Castelo-Loureiro A, García-Lorenzo E, Baena J, Herrera M, Enguita AB, Ruano Y, Zugazagoitia J, Paz-Ares L (2025).

Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC.

Jto Clinical And Research Reports. Article. 6(3):100778-100778.
[doi:10.1016/j.jtocrr.2024.100778]

2024

Jiménez-Reinoso, A, Molero-Abraham, M, Cirauqui, C, Blanco, B, Garrido-Martin, EM, Nehme-Alvarez, D, Domínguez-Alonso, C, Ramírez-Fernández, A, Díez-Alonso, L, Nuñez-Buiza, A, González-Murillo, A, Tobes, R, Pareja, E, Ramírez-Orellana, M, Rodriguez-Peralto, JL, Ferrer, I, Zugazagoitia, J, Paz-Ares, L, Alvarez-Vallina, L (2024).

CD4+ tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts

OncoImmunology. Article. 13(1):2392897-2392897.
[doi:10.1080/2162402X.2024.2392897]
Santoro, A, Pilar, G, Tan, DSW, Zugazagoitia, J, Shepherd, FA, Bearz, A, Barlesi, F, Kim, TM, Overbeck, TR, Felip, E, Cai, C, Simantini, E, Mcculloch, T, Schaefer, ES (2024).

Spartalizumab in combination with platinum-doublet chemotherapy with or without canakinumab in patients with PD-L1-unselected, metastatic NSCLC

BMC CANCER. Article. 24(1):1307-1307.
[doi:10.1186/s12885-024-12841-2]
Molero, A, Hernandez, S, Alonso, M, Peressini, M, Curto, D, Lopez-Rios, F, Conde, E (2024).

Assessment of PD-L1 expression and tumour infiltrating lymphocytes in early-stage non-small cell lung carcinoma with artificial intelligence algorithms

JOURNAL OF CLINICAL PATHOLOGY. Article. 78:456-464.
[doi:10.1136/jcp-2024-209766]
Zugazagoitia, J, Osma, H, Baena, J, Ucero, AC, Paz-Ares, L (2024).

Facts and Hopes on Cancer Immunotherapy for Small Cell Lung Cancer

CLINICAL CANCER RESEARCH. Review. 30(14):2872-2883.
[doi:10.1158/1078-0432.CCR-23-1159]
Peressini, M, Garcia-Campelo, R, Massuti, B, Marti, C, Cobo, M, Gutiérrez, V, Dómine, M, Fuentes, J, Majem, M, de Castro, J, Córdoba, JF, Diz, MP, Isla, D, Esteban, E, Carcereny, E, Vila, L, Moreno-Vega, A, Ros, S, Moreno, A, García, FJ, Huidobro, G, Aguado, C, Cebey-López, V, Valdivia, J, Palmero, R, Lianes, P, López-Brea, M, Vidal, OJ, Provencio, M, Arriola, E, Baena, J, Herrera, M, Bote, H, Molero, M, Adradas, V, Ponce-Aix, S, Nuñez-Buiza, A, Ucero, A, Hernandez, S, Lopez-Rios, F, Conde, E, Paz-Ares, L, Zugazagoitia, J (2024).

Spatially Preserved Multi-Region Transcriptomic Subtyping and Biomarkers of Chemoimmunotherapy Outcome in Extensive-Stage Small Cell Lung Cancer

CLINICAL CANCER RESEARCH. Article. 30(14):3036-3049.
[doi:10.1158/1078-0432.CCR-24-0104]
Nassar, AH, Kim, SY, Aredo, J, Feng, JM, Shepherd, F, Xu, C, Kaldas, D, Gray, JE, Dilling, TJ, Neal, JW, Wakelee, HA, Liu, YF, Lin, SH, Abuali, T, Amini, A, Nie, YA, Patil, T, Lobachov, A, Bar, J, Fitzgerald, B, Fujiwara, Y, Marron, TU, Thummalapalli, R, Yu, HLA, Owen, DH, Sharp, J, Farid, S, Rocha, P, Arriola, E, 'Aiello, A, Cheng, HY, Whitaker, R, Parikh, K, Ashara, Y, Chen, LX, Sankar, K, Harris, JP, Nagasaka, M, Ayanambakkam, A, Velazquez, AI, Ragavan, M, Lin, JJ, Piotrowska, ZF, Wilgucki, M, Reuss, J, Luders, H, Grohe, C, Espinar, JB, Feiner, E, Punekar, SR, Gupta, S, Leal, T, Kwiatkowski, DJ, Mak, RH, Adib, E, Naqash, AR, Goldberg, SB (2024).

Consolidation Osimertinib Versus Durvalumab Versus Observation After Concurrent Chemoradiation in Unresectable EGFR-Mutant NSCLC: A Multicenter Retrospective Cohort Study

JOURNAL OF THORACIC ONCOLOGY. Article. 19(6):928-940.
[doi:10.1016/j.jtho.2024.01.012]
Torres-Jiménez, J, Espinar, JB, de Cabo, HB, Berjaga, MZ, Esteban-Villarrubia, J, Fraile, JZ, Paz-Ares, L (2024).

Targeting KRASG12C in Non-Small-Cell Lung Cancer: Current Standards and Developments (Apr, 10.1007/s40265-024-02030-7, 2024)

DRUGS. Correction. 84(5):621-621.
[doi:10.1007/s40265-024-02044-1]
Torres-Jiménez, J, Espinar, JB, de Cabo, HB, Berjaga, MZ, Esteban-Villarrubia, J, Fraile, JZ, Paz-Ares, L (2024).

Targeting KRASG12C in Non-Small-Cell Lung Cancer: Current Standards and Developments

DRUGS. Review. 84(5):527-548.
[doi:10.1007/s40265-024-02030-7]

2023

Siringo M, Baena J, Bote de Cabo H, Torres-Jiménez J, Zurera M, Zugazagoitia J, Paz-Ares L (2023).

Future Perspectives in the Second Line Therapeutic Setting for Non-Oncogene Addicted Non-Small-Cell Lung Cancer.

Cancers. Review. 15(23).
[doi:10.3390/cancers15235505]
García-Campelo, R, Sullivan, I, Arriola, E, Insa, A, Vidal, OJ, Cruz-Castellanos, P, Morán, T, Reguart, N, Zugazagoitia, J, Dómine, M (2023).

SEOM-GECP Clinical guidelines for diagnosis, treatment and follow-up of small-cell lung cancer (SCLC) (2022) (vol 25, pg 2679, 2023)

CLINICAL & TRANSLATIONAL ONCOLOGY. Correction. 25(9):2760-2762.
[doi:10.1007/s12094-023-03290-7]
Ponce, S, Cedrés, S, Ricordel, C, Isambert, N, Viteri, S, Herrera-Juarez, M, Martinez-Marti, A, Navarro, A, Lederlin, M, Serres, X, Zugazagoitia, J, Vetrhus, S, Jaderberg, M, Hansen, TB, Levitsky, V, Paz-Ares, L (2023).

ONCOS-102 plus pemetrexed and platinum chemotherapy in malignant pleural mesothelioma: a randomized phase 2 study investigating clinical outcomes and the tumor microenvironment

Journal For Immunotherapy Of Cancer. Article. 11(9).
[doi:10.1136/jitc-2023-007552]
García-Campelo, R, Sullivan, I, Arriola, E, Insa, A, Vidal, O, Cruz-Castellanos, P, Morán, T, Reguart, N, Zugazagoitia, J, Dómine, M (2023).

SEOM-GECP Clinical guidelines for diagnosis, treatment and follow-up of small-cell lung cancer (SCLC) (2022)

CLINICAL & TRANSLATIONAL ONCOLOGY. Article. 25(9):2679-2691.
[doi:10.1007/s12094-023-03216-3]
Isla, D, Sánchez, A, Casal, J, Cobo, M, Majem, M, Reguart, N, Zugazagoitia, J, Bernabé, R (2023).

PD-1/PD-L1 Inhibitors as Monotherapy in the First-Line Treatment of Advanced Non-Small Cell Lung Cancer Patients with High PD-L1 Expression: An Expert Position Statement

Journal of Clinical Medicine. Article. 12(15).
[doi:10.3390/jcm12155063]
Exposito F, Redrado M, Houry M, Hastings K, Molero-Abraham M, Lozano T, Solorzano JL, Sanz-Ortega J, Adradas V, Amat R, Redin E, Leon S, Legarra N, Garcia J, Serrano D, Valencia K, Robles-Oteiza C, Foggetti G, Otegui N, Felip E, Lasarte JJ, Paz-Ares L, Zugazagoitia J, Politi K, Montuenga L, Calvo A (2023).

PTEN Loss Confers Resistance to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells.

CANCER RESEARCH. Article. 83(15):2513-2526.
[doi:10.1158/0008-5472.CAN-22-3023]
Hernandez, S, Conde, E, Alonso, M, Illarramendi, A, de Cabo, HB, Zugazagoitia, J, Paz-Ares, L, Lopez-Rios, F (2023).

A narrative review of methods for the identification of ALK fusions in patients with non-small cell lung carcinoma

Translational lung cancer research. Review. 12(7):1549-1562.
[doi:10.21037/tlcr-22-855]
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