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Ageing, Neuroimmunology and Nutrition

Publications

2024

Félix, J, de Toda, I, Cerro, E, González-Sánchez, M, De la Fuente, M (2024).

Frailty and biological age. Which best describes our aging and longevity?

MOLECULAR ASPECTS OF MEDICINE. Review. 98.
[doi:10.1016/j.mam.2024.101291]
Ceprián, N, de Toda, IM, Maté, I, Garrido, A, Gimenez-Llort, L, De la Fuente, M (2024).

Prodromic Inflammatory-Oxidative Stress in Peritoneal Leukocytes of Triple-Transgenic Mice for Alzheimer's Disease

International Journal Of Molecular Sciences. Article. 25(13).
[doi:10.3390/ijms25136976]
de Toda, IM, Félix, J, Díaz-Del Cerro, E, De la Fuente, M (2024).

Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice

Biogerontology. Article.
[doi:10.1007/s10522-024-10110-0]
Félix, J, de Toda, IM, Díaz-Del Cerro, EDD, Sánchez-Del Pozo, ISD, De la Fuente, M (2024).

Predictive Models of Life Span in Old Female Mice Based on Immune, Redox, and Behavioral Parameters

International Journal Of Molecular Sciences. Article. 25(8).
[doi:10.3390/ijms25084203]
Félix, J, de Toda, IM, Cerro, EDD, Gil-Agudo, F, De la Fuente, M (2024).

The immunity and redox clocks in mice, markers of lifespan

SCIENTIFIC REPORTS. Article. 14(1).
[doi:10.1038/s41598-024-51978-9]

2023

Díaz-Del Cerro, E, De la Fuente, M (2023).

Positive effects of pulsed electromagnetic fields on behavior, immune function, and oxidative and inflammatory state in old mice

ELECTROMAGNETIC BIOLOGY AND MEDICINE. Article.
[doi:10.1080/15368378.2023.2243994]
Diaz-Del Cerro, E, de Toda, IM, Félix, J, Baca, A, de la Fuente, M (2023).

Components of the Glutathione Cycle as Markers of Biological Age: An Approach to Clinical Application in Aging

Antioxidants. Article. 12(8).
[doi:10.3390/antiox12081529]
Valera, G, Figuer, A, Caro, J, Yuste, C, Morales, E, Ceprián, N, Bodega, G, Ramírez, R, Alique, M, Carracedo, J (2023).

Plasma glycocalyx pattern: a mirror of endothelial damage in chronic kidney disease

Clinical kidney journal. Article. 16(8):1278-1287.
[doi:10.1093/ckj/sfad051]
Garrido A, De la Fuente M (2023).

Could social relationships be key to reaching healthy longevity?

Aging-Us. Editorial Material. 15(12):5238-5239.
[doi:10.18632/aging.204871]
Sol J, Obis È, Mota-Martorell N, Pradas I, Galo-Licona JD, Martin-Garí M, Fernández-Bernal A, Ortega-Bravo M, Mayneris-Perxachs J, Borrás C, Viña J, De la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova JC, Brugada R, Ramos R, Serena J, Ramió-Torrentà L, Pineda V, Daunis-I-Estadella P, Thió-Henestrosa S, Barretina J, Garre-Olmo J, Portero-Otin M, Fernández-Real JM, Puig J, Jové M, Pamplona R (2023).

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.

Aging Cell. Article. 22(6).
[doi:10.1111/acel.13821]
Martínez-Alonso E, Escobar-Peso A, Guerra-Pérez N, Roca M, Masjuan J, Alcázar A (2023).

Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 24(9).
[doi:10.3390/ijms24098246]
Díaz-Del Cerro E, Félix J, De la Fuente M (2023).

El tacto, un sentido crucial en las interacciones sociales para mejorar la homeostasis en el envejecimiento y promover una longevidad saludable.

Revista espan~ola de geriatri´a y gerontologi´a. Article. 58(3):161-166.
[doi:10.1016/j.regg.2023.03.005]
Suarez, LM, Diaz-Del Cerro E, Felix, J, Gonzalez-Sanchez, M, Ceprian, N, Guerra-Perez, N, Novelle, MG, Martinez de Toda I, De la Fuente M (2023).

Sex differences in neuroimmunoendocrine communication. Involvement on longevity.

MECHANISMS OF AGEING AND DEVELOPMENT. Article. 211:111798-111798.
[doi:10.1016/j.mad.2023.111798]
Martínez de Toda I, González-Sánchez, M, Diaz-Del Cerro, E, Valera, G, Carracedo, J, Guerra-Pérez, N (2023).

Sex differences in markers of oxidation and inflammation. Implications for ageing.

MECHANISMS OF AGEING AND DEVELOPMENT. Article. 211:111797-111797.
[doi:10.1016/j.mad.2023.111797]
Félix, J, Garrido, A, de la Fuente, M (2023).

In Response to a Punctual Stress Male and Female Tyrosine Hydroxylase Haploinsufficient Mice Show a Deteriorated Behavior, Immunity, and Redox State

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 24(8).
[doi:10.3390/ijms24087335]
Díaz-Del Cerro E, Félix J, De la Fuente M (2023).

Skin-to-Skin Contact: Crucial for Improving Behavior, Immunity, and Redox State after Short Cohabitation of Chronologically Old Mice and Prematurely Aging Mice with Adult Mice.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 24(5).
[doi:10.3390/ijms24054680]
Baeta-Corral R, De la Fuente M, Giménez-Llort L (2023).

Sex-dependent worsening of NMDA-induced responses, anxiety, hypercortisolemia, and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling.

BEHAVIOURAL BRAIN RESEARCH. Article. 438:114189-114189.
[doi:10.1016/j.bbr.2022.114189]
Ceprian N, Garrido A, De la Fuente M (2023).

Mejoría de la inmunidad y la esperanza de vida en ratones maduros, genéticamente deficientes en la síntesis de catecolaminas, tras convivir con controles durante dos meses.

Revista espan~ola de geriatri´a y gerontologi´a. Article. 58(1):15-21.
[doi:10.1016/j.regg.2022.11.004]
Figuer, A, Alique, M, Valera, G, Serroukh, N, Ceprían, N, de Sequera, P, Morales, E, Carracedo, J, Ramirez, R, Bodega, G (2023).

New mechanisms involved in the development of cardiovascular disease in chronic kidney disease

NEFROLOGIA. Article. 43(1):63-80.
[doi:10.1016/j.nefro.2022.03.002]

2022

González-Bermúdez B, Kobayashi H, Abarca-Ortega A, Córcoles-Lucas M, González-Sánchez M, De la Fuente M, Guinea GV, Elices M, Plaza GR (2022).

Aging is accompanied by T-cell stiffening and reduced interstitial migration through dysfunctional nuclear organization.

Immunology. Article. 167(4):622-639.
[doi:10.1111/imm.13559]
González-Sánchez M, García-Martínez V, Bravo S, Kobayashi H, Martínez de Toda I, González-Bermúdez B, Plaza GR, De la Fuente M (2022).

Mitochondrial DNA insertions into nuclear DNA affecting chromosome segregation: Insights for a novel mechanism of immunosenescence in mice.

MECHANISMS OF AGEING AND DEVELOPMENT. Article. 207:111722-111722.
[doi:10.1016/j.mad.2022.111722]
Gonzalez-Bermudez, B, Abarca-Ortega, A, Gonzalez-Sanchez, M, De la Fuente, M, Plaza, GR (2022).

Possibilities of using T-cell biophysical biomarkers of ageing.

EXPERT REVIEWS IN MOLECULAR MEDICINE. Review. 24.
[doi:10.1017/erm.2022.29]
Garrido A, De la Fuente M (2022).

Social environment improves the cytokine profile and lymphoproliferative response in chronologically old and prematurely aging mice.

MECHANISMS OF AGEING AND DEVELOPMENT. Article. 206:111692-111692.
[doi:10.1016/j.mad.2022.111692]
Garrido A, Martínez de Toda I, Díaz Del Cerro E, Félix J, Ceprián N, González-Sánchez M, De la Fuente M (2022).

Social environment as a modulator of immunosenescence.

EXPERT REVIEWS IN MOLECULAR MEDICINE. Review. 24.
[doi:10.1017/erm.2022.24]
Díaz-Del Cerro E, Félix J, Tresguerres J, De la Fuente M (2022).

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields.

ENVIRONMENTAL HEALTH. Article. 21(1):72-72.
[doi:10.1186/s12940-022-00882-8]
Hunsche, C, Hernandez, O, Mela, V, Viveros, MP, De la Fuente, M (2022).

The Postnatal Leptin Surge Supports Immune Cell Function in Rats.

IMMUNOLOGICAL INVESTIGATIONS. Article. 51(5):1-17.
[doi:10.1080/08820139.2021.1940199]
Cerro ED, Félix J, De la Fuente M (2022).

Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice.

Biogerontology. Article. 23(3):307-324.
[doi:10.1007/s10522-022-09968-9]
Ramírez R, Ceprian N, Figuer A, Valera G, Bodega G, Alique M, Carracedo J (2022).

Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis.

Journal of Personalized Medicine. Article. 12(2).
[doi:10.3390/jpm12020215]
Diaz-Del Cerro, E, Lambea, M, Felix, J, Salazar, N, Gueimonde, M, De la Fuente, M (2022).

Daily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice

Biogerontology. Article. 23(1):35-52.
[doi:10.1007/s10522-021-09943-w]
Diaz-del Cerro, E, Ceprian, N, Felix, J, De la Fuente, M (2022).

A short social interaction between adult and old mice improves the homeostatic systems and increases healthy longevity

EXPERIMENTAL GERONTOLOGY. Article. 158:111653-111653.
[doi:10.1016/j.exger.2021.111653]

2021

de Toda, IM, Ceprian, N, Cerro, EDD, De la Fuente, M (2021).

The Role of Immune Cells in Oxi-Inflamm-Aging

Cells. Review. 10(11).
[doi:10.3390/cells10112974]
Maté I, Martínez de Toda I, Arranz L, Álvarez-Sala JL, De la Fuente M (2021).

Accelerated immunosenescence, oxidation and inflammation lead to a higher biological age in COPD patients.

EXPERIMENTAL GERONTOLOGY. Article. 154:111551-111551.
[doi:10.1016/j.exger.2021.111551]
Martínez de Toda I, Vida, C, Diaz-Del Cerro, E, De la Fuente, M (2021).

The Immunity Clock.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 76(11):1939-1945.
[doi:10.1093/gerona/glab136]
Ceprian N, Valera G, Caro J, Yuste C, Serroukh N, González de Pablos I, Oliva C, Figuer A, Praga M, Alique M, Ramirez R, Morales E, Carracedo J (2021).

Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.

Frontiers in medicine. Article. 8:705159-705159.
[doi:10.3389/fmed.2021.705159]
Garrido A, Cruces J, Ceprián N, Hernández-Sánchez C, De Pablo F, De la Fuente M (2021).

Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice

JOURNAL OF NEUROIMMUNE PHARMACOLOGY. Article. 16(3):548-566.
[doi:10.1007/s11481-020-09947-2]
Martínez de Toda I, Rattan SIS, De la Fuente M, Arranz L (2021).

Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities.

Antioxidants. Article. 10(9).
[doi:10.3390/antiox10091397]
Figuer A, Bodega G, Tato P, Valera G, Serroukh N, Ceprian N, de Sequera P, Morales E, Carracedo J, Ramírez R, Alique M (2021).

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. Review. 18(15).
[doi:10.3390/ijerph18158044]
Vida C, Oliva C, Yuste C, Ceprián N, Caro PJ, Valera G, González de Pablos I, Morales E, Carracedo J (2021).

Oxidative Stress in Patients with Advanced CKD and Renal Replacement Therapy: The Key Role of Peripheral Blood Leukocytes.

Antioxidants. Article. 10(7).
[doi:10.3390/antiox10071155]
Vida C, Carracedo J, de Sequera P, Bodega G, Pérez R, Alique M, Ramírez R (2021).

A high magnesium concentration in citrate dialysate prevents oxidative stress and damage in human monocytes in vitro.

Clinical kidney journal. Article. 14(5):1403-1411.
[doi:10.1093/ckj/sfaa131]
Garrido, A, de La Serna, M, de La Fuente, M, Marco, EM, Lopez-Gallardo, M (2021).

Neuronal and glial region dependent changes in female mice from a model of premature aging

EXPERIMENTAL GERONTOLOGY. Article. 146:111224-111224.
[doi:10.1016/j.exger.2020.111224]
Kobayashi H, Martínez de Toda I, Sanz-San Miguel L, De la Fuente M (2021).

Sex-related differences in behavioural markers in adult mice for the prediction of lifespan

Biogerontology. Article. 22(1):49-62.
[doi:10.1007/s10522-020-09902-x]
De la Fuente M (2021).

The Role of the Microbiota-Gut-Brain Axis in the Health and Illness Condition: A Focus on Alzheimer's Disease.

JOURNAL OF ALZHEIMERS DISEASE. Review. 81(4):1345-1360.
[doi:10.3233/JAD-201587]

2020

De la Fuente M, Sánchez C, Vallejo C, Díaz-Del Cerro E, Arnalich F, Hernanz Á (2020).

Vitamin C and vitamin C plus E improve the immune function in the elderly.

EXPERIMENTAL GERONTOLOGY. Article. 142:111118-111118.
[doi:10.1016/j.exger.2020.111118]
Cerro, EDD, Vida, C, de Toda, IM, Felix, J, De la Fuente, M (2020).

The use of a bed with an insulating system of electromagnetic fields improves immune function, redox and inflammatory states, and decrease the rate of aging

ENVIRONMENTAL HEALTH. Article. 19(1).
[doi:10.1186/s12940-020-00674-y]
Martínez De Toda I, Vida, C, Garcia-Salmones, M, Alonso-Fernandez, P, De La Fuente, M (2020).

Immune function, oxidative and inflammatory markers in centenarians as potential predictors of survival and indicators of recovery after hospital admission.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 75(10):1827-1833.
[doi:10.1093/gerona/glz250]
Hunsche C, Martínez de Toda I, Hernandez O, Jiménez B, Díaz LE, Marcos A, De la Fuente M (2020).

The supplementations with 2-hydroxyoleic acid and n-3 polyunsaturated fatty acids revert oxidative stress in various organs of diet-induced obese mice.

Free Radical Research. Article. 54(6):455-466.
[doi:10.1080/10715762.2020.1800004]
Bermejo-Pareja, F, del Ser, T, Valenti, M, de la Fuente, M, Bartolome, F, Carro, E (2020).

Salivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions.

ALZHEIMERS & DEMENTIA. Article. 16(8):1196-1204.
[doi:10.1002/alz.12107]
Puertas MJ, González-Sánchez M (2020).

Insertions of mitochondrial DNA into the nucleus-effects and role in cell evolution.

Genome. Article. 63(8):365-374.
[doi:10.1139/gen-2019-0151]
Gonzalez-Bermudez, B, Kobayashi, H, Navarrete, A, Nyblad, C, Gonzalez-Sanchez, M, de la Fuente, M, Fuentes, G, Guinea, GV, Garcia, C, Plaza, GR (2020).

Single-cell biophysical study reveals deformability and internal ordering relationship in T cells

Soft Matter. Article. 16(24):5669-5678.
[doi:10.1039/d0sm00648c]
Garrido, A, Cruces, J, Ceprian, N, Diaz-Del Cerro, E, Felix, J, De la Fuente, M (2020).

The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.

JOURNAL OF NEUROIMMUNOLOGY. Article. 343:577240-577240.
[doi:10.1016/j.jneuroim.2020.577240]
Vida, C, Carracedo, J, Sequera P, Bodega, G, Perez, R, Alique, M, Ramirez, R (2020).

Increasing the Magnesium Concentration in Various Dialysate Solutions Differentially Modulates Oxidative Stress in a Human Monocyte Cell Line.

Antioxidants. Article. 9(4).
[doi:10.3390/antiox9040319]
Martinez de Toda I, Vida, C, Garrido, A, De la Fuente, M (2020).

Redox parameters as markers of the rate of aging and predictors of lifespan.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 75(4):613-620.
[doi:10.1093/gerona/glz033]
Alique, M, Sanchez-Lopez, E, Bodega, G, Giannarelli, C, Carracedo, J, Ramirez, R (2020).

Hypoxia-Inducible Factor-1alpha: The Master Regulator of Endothelial Cell Senescence in Vascular Aging.

Cells. Review. 9(1).
[doi:10.3390/cells9010195]
Alique, M, Bodega, G, Corchete, E, Garcia-Menendez, E, de Sequera, P, Luque, R, Rodriguez-Padron, D, Marques, M, Portoles, J, Carracedo, J, Ramirez, R (2020).

Microvesicles from indoxyl sulfate-treated endothelial cells induce vascular calcification in vitro.

Computational and Structural Biotechnology Journal. Article. 18:953-966.
[doi:10.1016/j.csbj.2020.04.006]
Carracedo, J, Alique, M, Vida, C, Bodega, G, Ceprian, N, Morales, E, Praga, M, de Sequera, P, Ramirez, R (2020).

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence.

Frontiers In Cell And Developmental Biology. Review. 8:185-185.
[doi:10.3389/fcell.2020.00185]

2019

Martínez de Toda I, Miguelez, L, Siboni, L, Vida, C, De la Fuente, M (2019).

High perceived stress in women is linked to oxidation, inflammation and immunosenescence.

Biogerontology. Article. 20(6):823-835.
[doi:10.1007/s10522-019-09829-y]
Bodega, G, Alique, M, Puebla, L, Carracedo, J, Ramirez, RM (2019).

Microvesicles: ROS scavengers and ROS producers

Journal of extracellular vesicles. Review. 8(1):1626654-1626654.
[doi:10.1080/20013078.2019.1626654]
De la Fuente M (2019).

Where Could Research on Immunosenescence Lead?

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Editorial Material. 20(23).
[doi:10.3390/ijms20235906]
Useros, NR, Gheorghe, A, de Heredia, FP, Diaz, LE, Baccan, GC, de la Fuente, M, Marcos, A (2019).

2-OHOA supplementation reduced adiposity and improved cardiometabolic risk to a greater extent than n-3 PUFA in obese mice

OBESITY RESEARCH & CLINICAL PRACTICE. Article. 13(6):579-585.
[doi:10.1016/j.orcp.2019.10.009]
Giménez-Llort L, Ramírez-Boix P, De la Fuente M (2019).

Mortality of septic old and adult male mice correlates with individual differences in premorbid behavioral phenotype and acute-phase sickness behavior.

EXPERIMENTAL GERONTOLOGY. Article. 127:110717-110717.
[doi:10.1016/j.exger.2019.110717]
Hunsche, C, Cruces, J, De la Fuente, M (2019).

Improvement of Redox State and Functions of Immune Cells as Well as of Behavioral Response in Aged Mice After Two-Week Supplementation of Fermented Milk with Probiotics.

CURRENT MICROBIOLOGY. Article. 76(11):1278-1289.
[doi:10.1007/s00284-019-01759-9]
Martínez de Toda I, Vida, C, Sanz San Miguel L, De la Fuente, M (2019).

When will my mouse die? Life span prediction based on immune function, redox and behavioural parameters in female mice at the adult age.

MECHANISMS OF AGEING AND DEVELOPMENT. Article. 182:111125-111125.
[doi:10.1016/j.mad.2019.111125]
Daza, Rafael, Gonzalez-Bermudez, Blanca, Cruces, Julia, De la Fuente, Monica, Plaza, Gustavo R., Arroyo-Hernandez, Maria, Elices, Manuel, Perez-Rigueiro, Jose, Guinea, Gustavo V. (2019).

Comparison of cell mechanical measurements provided by Atomic Force Microscopy (AFM) and Micropipette Aspiration (MPA)

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. Article. 95:103-115.
[doi:10.1016/j.jmbbm.2019.03.031]
Martínez de Toda I, Vida, C, Sanz San Miguel L, De la Fuente, M (2019).

Function, Oxidative, and Inflammatory Stress Parameters in Immune Cells as Predictive Markers of Lifespan throughout Aging.

Oxidative Medicine And Cellular Longevity. Article. 2019:4574276-4574276.
[doi:10.1155/2019/4574276]
Alique, M, Bodega, G, Giannarelli, C, Carracedo, J, Ramirez, R (2019).

MicroRNA-126 regulates Hypoxia-Inducible Factor-1a which inhibited migration, proliferation, and angiogenesis in replicative endothelial senescence.

SCIENTIFIC REPORTS. Article. 9(1):7381-7381.
[doi:10.1038/s41598-019-43689-3]
Hunsche, C, de Toda, IM, de la Fuente, M (2019).

Impacts of the late adulthood diet-induced obesity onset on behavior, immune function, redox state and life span of male and female mice.

BRAIN BEHAVIOR AND IMMUNITY. Article. 78:65-77.
[doi:10.1016/j.bbi.2019.01.010]
Fernández-García C, Rancan L, Paredes SD, Montero C, De la Fuente M, Vara E, Tresguerres JAF (2019).

Xanthohumol exerts protective effects in liver alterations associated with aging.

EUROPEAN JOURNAL OF NUTRITION. Article. 58(2):653-663.
[doi:10.1007/s00394-018-1657-6]
Rodelo-Haad, C, Aguera, ML, Carmona, A, Navarro, MD, Carracedo, J, Rodriguez-Benot, A, Aljama, P (2019).

Pancreatic autoantibodies and CD14(+)CD16(+) monocytes subset are associated with the impairment of beta-cell function after simultaneous pancreas-kidney transplantation

PLOS ONE. Article. 14(2).
[doi:10.1371/journal.pone.0212547]
Vida, C, Kobayashi, H, Garrido, A, Martinez de Toda, I, Carro, E, Molina, JA, De la Fuente, M (2019).

Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson's Disease Patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 20(3).
[doi:10.3390/ijms20030771]
Garrido, A, Cruces, J, Ceprian, N, Vara, E, de la Fuente, M (2019).

Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 20(3).
[doi:10.3390/ijms20030769]
Garrido, A, Cruces, J, Ceprian, N, Corpas, I, Tresguerres, JA, De la Fuente, M (2019).

Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan

Biogerontology. Article. 20(1):49-69.
[doi:10.1007/s10522-018-9774-4]
Carracedo, J, Alique, M, Ramirez-Carracedo, R, Bodega, G, Ramirez, R (2019).

Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus.

CURRENT VASCULAR PHARMACOLOGY. Review. 17(5):447-454.
[doi:10.2174/1570161116666180820115726]
Requena, T, Hernandez, P, Arauzo, B, Ceprian, N, De la Serna, M, Martinez-Cuesta, MC, Pelaez, C, De la Fuente, M (2019).

MODULATION BY LACTOBACILLUS RHAMNOSUS GG OF MICROBIOTA AND INNATE IMMUNE FUNCTIONS IN CHRONOLOGICAL OLD AND ADULT PREMATURE AGEING MICE

ANNALS OF NUTRITION AND METABOLISM. Meeting Abstract. 74:21-21.
Cabeza, IMD, Vida, C, De la Fuente, M (2019).

An equation based on mice behaviour at the adult age predicts lifespan

EUROPEAN NEUROPSYCHOPHARMACOLOGY. Meeting Abstract. 29:205-205.
[doi:10.1016/j.euroneuro.2018.11.339]
Martínez de Toda I, Miguelez, L, Vida, C, Carro, E, De la Fuente, M (2019).

Altered Redox State in Whole Blood Cells from Patients with Mild Cognitive Impairment and Alzheimer's Disease.

JOURNAL OF ALZHEIMERS DISEASE. Article. 71(1):153-163.
[doi:10.3233/JAD-190198]

2018

Martinez de Toda I, Garrido, A, Vida, C, Gomez-Cabrera, MC, Vina, J, De la Fuente, M (2018).

Frailty Quantified by the "Valencia Score" as a Potentia l Predictor of Lifespan in Mice

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 73(10):1323-1329.
[doi:10.1093/gerona/gly064]
Alique, M, Ramirez-Carracedo, R, Bodega, G, Carracedo, J, Ramirez, R (2018).

Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Review. 19(7).
[doi:10.3390/ijms19072003]
Garrido, A, Cruces, J, Ceprian, N, De la Fuente, M (2018).

Improvements in Behavior and Immune Function and Increased Life Span of Old Mice Cohabiting With Adult Animals

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 73(7):873-881.
[doi:10.1093/gerona/gly043]
Ceprian, N, Gonzalez, A, Garrido, A, Cruces, J, Diaz, E, De la Fuente, M (2018).

The oxidative stress in organs from tyrosine hydroxylase haploinsufficient mice could be ameliorated by their social environment

FREE RADICAL BIOLOGY AND MEDICINE. Meeting Abstract. 120:98-98.
[doi:10.1016/j.freeradbiomed.2018.04.326]
de Toda, IM, Vida, C, Garrido, A, De la Fuente, M (2018).

Oxidative stress parameters as markers of the rate of aging and longevity in mice

FREE RADICAL BIOLOGY AND MEDICINE. Meeting Abstract. 120:103-104.
[doi:10.1016/j.freeradbiomed.2018.04.342]
Miguelez, L, de Toda, IM, De la Fuente, M (2018).

Oxidative stress in blood cells of men and women with Alzheimer's and Parkinson's diseases

FREE RADICAL BIOLOGY AND MEDICINE. Meeting Abstract. 120:98-98.
[doi:10.1016/j.freeradbiomed.2018.04.325]
Vida, C, Montalvo, A, Garcia-Martin, M, De la Fuente, M (2018).

A high neuroticism is accompanied by oxidative stress in peripheral blood cells of healthy young subjects

FREE RADICAL BIOLOGY AND MEDICINE. Meeting Abstract. 120:103-103.
[doi:10.1016/j.freeradbiomed.2018.04.341]
Carracedo, J, Ramirez-Carracedo, R, Martinez de Toda I, Vida, C, Alique, M, De la Fuente, M, Ramirez-Chamond, R (2018).

Protein Carbamylation: A Marker Reflecting Increased Age-Related Cell Oxidation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 19(5).
[doi:10.3390/ijms19051495]
Hunsche, C, Hernandez, O, Gheorghe, A, Diaz, LE, Marcos, A, De la Fuente, M (2018).

Immune dysfunction and increased oxidative stress state in diet-induced obese mice are reverted by nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids

EUROPEAN JOURNAL OF NUTRITION. Article. 57(3):1123-1135.
[doi:10.1007/s00394-017-1395-1]
Garrido, A, Cruces, J, Ceprian, N, Hernandez-Sanchez, C, De la Fuente, M (2018).

Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study

BRAIN BEHAVIOR AND IMMUNITY. Article. 69:440-455.
[doi:10.1016/j.bbi.2018.01.003]
Vida, C, de Toda, IM, Garrido, A, Carro, E, Molina, JA, De la Fuente, M (2018).

Impairment of Several Immune Functions and Redox State in Blood Cells of Alzheimer's Disease Patients. Relevant Role of Neutrophils in Oxidative Stress

Frontiers in immunology. Article. 8.
[doi:10.3389/fimmu.2017.01974]

2017

García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI, Alén F, Botta J, McCormick PJ, Ballesteros JA, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML (2017).

A Positive Allosteric Modulator of the Serotonin 5-HT2c Receptor for Obesity

JOURNAL OF MEDICINAL CHEMISTRY. Article. 60(23):9575-9584.
[doi:10.1021/acs.jmedchem.7b00994]
Diaz-Tocados JM, Peralta-Ramirez A, Rodríguez-Ortiz ME, Raya AI, Lopez I, Pineda C, Herencia C, Montes de Oca A, Vergara N, Steppan S, Pendon-Ruiz de Mier MV, Buendía P, Carmona A, Carracedo J, Alcalá-Díaz JF, Frazao J, Martínez-Moreno JM, Canalejo A, Felsenfeld A, Rodriguez M, Aguilera-Tejero E, Almadén Y, Muñoz-Castañeda JR (2017).

Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats

KIDNEY INTERNATIONAL. Article. 92(5):1084-1099.
[doi:10.1016/j.kint.2017.04.011]
Rancán L, Paredes SD, García I, Muñoz P, García C, López de Hontanar G, de la Fuente M, Vara E, Tresguerres JAF (2017).

Protective effect of xanthohumol against age-related brain damage

JOURNAL OF NUTRITIONAL BIOCHEMISTRY. Article. 49:133-140.
[doi:10.1016/j.jnutbio.2017.07.011]
Valencia-Nuñez DM, Kreutler W, Moya-Gonzalez J, Alados-Arboledas P, Muñoz-Carvajal I, Carmona A, Ramirez-Chamond R, Carracedo-Añon J (2017).

Endothelial vascular markers in coronary surgery

HEART AND VESSELS. Article. 32(11):1390-1399.
[doi:10.1007/s00380-017-1006-3]
Mela V, Hernandez O, Hunsche C, Diaz F, Chowen JA, De la Fuente M (2017).

Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats

MOLECULAR AND CELLULAR ENDOCRINOLOGY. Article. 454(C):125-134.
[doi:10.1016/j.mce.2017.06.018]
Carmona A, Guerrero F, Buendia P, Obrero T, Aljama P, Carracedo J (2017).

Microvesicles Derived from Indoxyl Sulfate Treated Endothelial Cells Induce Endothelial Progenitor Cells Dysfunction

Frontiers in physiology. Article. 8:666-666.
[doi:10.3389/fphys.2017.00666]
Vida C, de Toda IM, Cruces J, Garrido A, Gonzalez-Sanchez M, De la Fuente M (2017).

Role of macrophages in age-related oxidative stress and lipofuscin; accumulation in mice

Redox Biology. Article. 12:423-437.
[doi:10.1016/j.redox.2017.03.005]
Martínez de Toda I, Vida C, De la Fuente M (2017).

An Appropriate Modulation of Lymphoproliferative Response and Cytokine; Release as Possible Contributors to Longevity

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 18(7).
[doi:10.3390/ijms18071598]
Gheorghe A, Pérez de Heredia F, Hunsche C, Redondo N, Díaz LE, Hernández O, Marcos A, De la Fuente M (2017).

Oxidative stress and immunosenescence in spleen of obese mice can be; reversed by 2-hydroxyoleic acid

EXPERIMENTAL PHYSIOLOGY. Article. 102(5):533-544.
[doi:10.1113/EP086157]
Esteban-Manzanares G, González-Bermúdez B, Cruces J, De la Fuente M, Li Q, Guinea GV, Pérez-Rigueiro J, Elices M, Plaza GR (2017).

Improved Measurement of Elastic Properties of Cells by Micropipette Aspiration and Its Application to Lymphocytes

ANNALS OF BIOMEDICAL ENGINEERING. Article. 45(5):1375-1385.
[doi:10.1007/s10439-017-1795-7]
Carmona A, Agüera ML, Luna-Ruiz C, Buendía P, Calleros L, García-Jerez A, Rodríguez-Puyol M, Arias M, Arias-Guillen M, de Arriba G, Ballarin J, Bernis C, Fernández E, García-Rebollo S, Mancha J, Del Peso G, Pérez E, Poch E, Portolés JM, Rodríguez-Puyol D, Sánchez-Villanueva R, Sarro F, Torres A, Martín-Malo A, Aljama P, Ramírez R, Carracedo J (2017).

Markers of endothelial damage in patients with chronic kidney disease on hemodialysis

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. Article. 312(4):673-681.
[doi:10.1152/ajprenal.00013.2016]
Ardura JA, Portal-Núñez S, Castelbón-Calvo I, Martínez de Toda I, De la Fuente M, Esbrit P (2017).

Parathyroid Hormone-Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase

JOURNAL OF CELLULAR PHYSIOLOGY. Article. 232(4):785-796.
[doi:10.1002/jcp.25473]
Alique M, Ruíz-Torres MP, Bodega G, Noci MV, Troyano N, Bohórquez L, Luna C, Luque R, Carmona A, Carracedo J, Ramírez R (2017).

Microvesicles from the plasma of elderly subjects and from senescent; endothelial cells promote vascular calcification

Aging-Us. Article. 9(3):778-789.
[doi:10.18632/aging.101191]
Garrido A, Cruces J, Iriarte I, Hernández-Sánchez C, de Pablo F, de la Fuente M (2017).

Inmunosenescencia prematura en ratones con una deficiencia en la sintesis de catecolaminas. Efecto del ambiente social.

Revista espan~ola de geriatri´a y gerontologi´a. Article. 52(1):20-26.
[doi:10.1016/j.regg.2016.01.002]

2016

Borras, Consuelo, Abdelaziz, Kheira M., Gambini, Juan, Serna, Eva, Ingles, Marta, de la Fuente, Monica, Garcia, Idoia, Matheu, Ander, Sanchis, Paula, Belenguer, Angel, Errigo, Alessandra, Avellana, Juan-Antonio, Barettino, Ana, Lloret-Fernandez, Carla, Flames, Nuria, Pes, Gianni, Rodriguez-Manas, Leocadio, Vina, Jose (2016).

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging

Aging-Us. Article. 8(12):3185-3185.
[doi:10.18632/aging.101078]
de Toda IM, Vida C, Ortega E, De La Fuente M (2016).

Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice

EXPERIMENTAL GERONTOLOGY. Article. 84:21-28.
[doi:10.1016/j.exger.2016.08.013]
Martinez de Toda, Irene, Mate, Ianire, Vida, Carmen, Cruces, Julia, De la Fuente, Monica (2016).

Immune function parameters as markers of biological age and predictors of longevity

Aging-Us. Article. 8(11):3110-3119.
[doi:10.18632/aging.101116]
Bauer ME, Fuente Mde L (2016).

The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

MECHANISMS OF AGEING AND DEVELOPMENT. Article. 158(SI):27-37.
[doi:10.1016/j.mad.2016.01.001]
Hunsche C, Hernandez O, De la Fuente M (2016).

Impaired Immune Response in Old Mice Suffering from Obesity and Premature Immunosenescence in Adulthood

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 71(8):983-991.
[doi:10.1093/gerona/glv082]
Jové M, Maté I, Naudí A, Mota-Martorell N, Portero-Otín M, De la Fuente M, Pamplona R (2016).

Human Aging Is a Metabolome-related Matter of Gender

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 71(5):578-585.
[doi:10.1093/gerona/glv074]
Portal-Nunez, S, Ardura, JA, Lozano, D, Bolivar, OH, Lopez-Herradon, A, Gutierrez-Rojas, I, Proctor, A, van der Eerden, B, Schreuders-Koedam, M, van Leeuwen, J, Alcaraz, MJ, Mulero, F, de la Fuente, M, Esbrit, P (2016).

Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. Article. 71(3):290-299.
[doi:10.1093/gerona/glv160]

2015

de Toda, I. Martinez, De la Fuente, M. (2015).

The role of Hsp70 in oxi-inflamm-aging and its use as a potential biomarker of lifespan

Biogerontology. Review. 16(6):709-721.
[doi:10.1007/s10522-015-9607-7]
Cruces, Julia, Portal-Nunez, Sergio, Fernandez-Tresguerres, Jesus A., De la Fuente, Monica (2015).

Loneliness and social isolation worsen immunity in the elderly

Approaches To Aging Control. Article. 7-16.
Daza R, Cruces J, Arroyo-Hernández M, Marí-Buyé N, De la Fuente M, Plaza GR, Elices M, Pérez-Rigueiro J, Guinea GV (2015).

Topographical and mechanical characterization of living eukaryotic cells on opaque substrates: development of a general procedure and its application to the study of non-adherent lymphocytes

PHYSICAL BIOLOGY. Article. 12(2):26005-26005.
[doi:10.1088/1478-3975/12/2/026005]
Maté I, Cruces J, Giménez-Llort L, De la Fuente M (2015).

Function and Redox State of Peritoneal Leukocytes as Preclinical and Prodromic Markers in a Longitudinal Study of Triple-Transgenic Mice for Alzheimer's Disease

JOURNAL OF ALZHEIMERS DISEASE. Article. 43(1):213-226.
[doi:10.3233/JAD-140861]

2014

Cruces, Julia, Venero, Cesar, Pereda-Perez, Inmaculada, De la Fuente, Monica (2014).

A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response

JOURNAL OF NEUROIMMUNOLOGY. Article. 277(1-2):18-25.
[doi:10.1016/j.jneuroim.2014.09.011]
De Palma, G., Vida, C., Santacruz, A., De Castro, N. M., De la Fuente, M., Sanz, Y. (2014).

Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence

JOURNAL OF NEUROIMMUNOLOGY. Article. 276(1-2):47-57.
[doi:10.1016/j.jneuroim.2014.08.007]
Gomez, Alexia, Sanchez-Roman, Ines, Gomez, Jose, Cruces, Julia, Mate, Ianire, Lopez-Torres, Monica, Naudi, Alba, Portero-Otin, Manuel, Pamplona, Reinald, De la Fuente, Monica, Barja, Gustavo (2014).

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

Aging Cell. Article. 13(3):551-560.
[doi:10.1111/acel.12205]
Gimenez-Llort, Lydia, Torres-Lista, Virginia, De la Fuente, Monica (2014).

Crosstalk between Behavior and Immune System During the Prodromal Stages of Alzheimer's Disease

CURRENT PHARMACEUTICAL DESIGN. Article. 20(29):4723-4732.
Cruces, Julia, Venero, Cesar, Pereda-Perez, Inmaculada, De la Fuente, Monica (2014).

The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication

CURRENT PHARMACEUTICAL DESIGN. Article. 20(29):4608-4628.
Mate, Ianire, Antonio Madrid, Juan, De la Fuente, Monica (2014).

Chronobiology of the Neuroimmunoendocrine System and Aging

CURRENT PHARMACEUTICAL DESIGN. Article. 20(29):4642-4655.
Vida, Carmen, Gonzalez, Eva M., De la Fuente, Monica (2014).

Increase of Oxidation and Inflammation in Nervous and Immune Systems with Aging and Anxiety

CURRENT PHARMACEUTICAL DESIGN. Article. 20(29):4656-4678.

Martínez de Toda I, Maté I, Vida C, Cruces J, De la Fuente M ().

Immune function parameters as markers of biological age and predictors of longevity.

Aging-Us. Article.