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Pulmonary Surfactant and Respiratory Diseases


Scientific objectives and lines of work

  • Composition and structural characteristics of the pulmonary surfactant seeking its greatest therapeutic efficacy.
  • Functional tests with a captive bubble surfactometer.
  • Analysis of the lipid composition of the surfactants.
  • Dynamics, understanding-expansion and stability of the surfactants.
  • Pathogenesis of the inactivation of the surfactant in acute lung damage.
  • Screening tests for surfactant replacement in preterm infants.
  • Nanotoxicity: the study of the impact of certain drugs, liposomes and nanoparticles on the structure and function of the pulmonary surfactant.
  • Nanopharmacology: the study of the pulmonary surfactant as a route for drug administration. Surfactant-promoted diffusion of the pharmaceuticals towards the alveoli.
  • Biophysical models used to optimize interface vehiculation.