Translational Research in Malaria |

Publications

2025

Segovia, JC, Ramírez, JC, Río, P, Lotufo, CM, López-Bueno, A, Calvo-López, T, Lamana, ML, Sandonís, V, Balas, A, Bautista, JM, Abad, P, Azcárate, IG, Lorenzo, JLL, Jalilian, FA, Amini, R, Kinnunen, PM, Jokelainen, P, Mohanraj, U, Söderlund-Venermo, M, Almendral, JM (2025).

A presumed mouse parvovirus with overlooked high toxicity for human primitive CD34+ hematopoietic precursors in vitro and in bone marrow-humanized mice

Microbiology Spectrum. Article. 13(12).
[doi:10.1128/spectrum.02339-25]

Hernando-Ospina, N, Calero, M, Solís, G, Azcárate, IG, Herráez-Aguilar, D, Caselli, N, Moleiro, LH, Segovia, J, Bautista, JM, Monroy, F (2025).

Metabolic Rigidity as a Mechanical Barrier to Malaria: Flickering Loss in PKLR-Deficient Erythrocytes

FASEB JOURNAL. Article. 39(22).
[doi:10.1096/fj.202502505R]

Rossi, N, Benítez-Cruz, J, Marín-García, P, Azcárate, IG, González-Escalada, A, Hervás, OG, Alarcón, B, Regueiro, JR, Bautista, JM, Martinez-Quiles, N (2025).

Post-COVID syndrome patients show reduced anti-Spike antibodies compared to COVID-recovered controls, but enhanced IgG4/IgG1 switch after the third vaccine dose

Frontiers in Immunology. Article. 16.
[doi:10.3389/fimmu.2025.1670324]

Ovejero-Paredes, K, Bisbano, G, Flier, I, González-Simón, A, Marciello, M, Oliveira, S, Zupi, M, Rubes, D, Ayash, F, Doria, F, Pirota, V, Terreni, M, Serra, M, Filice, M (2025).

Microfluidic-assisted synthesis of integrin-targeting cRGD liposomes as a scalable strategy for theranostic applications in triple-negative breast cancer

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. Article. 213.
[doi:10.1016/j.ejps.2025.107216]

Abad, P, Pérez-Benavente, S, Pérez-Luz, S, Fobil, JN, Luyenga, BK, Mukendi, AK, Puyet, A, Diez, A, Luzzatto, L, Azcárate, IG, Bautista, JM (2025).

Coinheritance of polymorphic alleles of PIEZO1, G6PD and HBB enhances protection against malaria

One Health. Article. 20.
[doi:10.1016/j.onehlt.2025.101051]

Moleiro, LH, Herráez-Aguilar, D, Solís-Fernández, G, Caselli, N, Dargel, C, Dodero, VI, Bautista, JM, Hellweg, T, Monroy, F (2025).

Mechanical adaptivity of red blood cell flickering to extrinsic membrane stiffening by the solid-like biosurfactant b-Aescin

BIOPHYSICAL JOURNAL. Article. 124(9):1478-1495.
[doi:10.1016/j.bpj.2025.03.027]

de la Torre, MH, Covaleda-Cortés, G, Montesinos, L, Covaleda, D, Ortiz, JC, Piñol, J, Bautista, JM, Castillo, JP, Reverter, D, Aviles, FX (2025).

Analysis of Protein Inhibitors of Trypsin in Quinoa, Amaranth and Lupine Seeds. Selection and Deep Structure-Function Characterization of the Amaranthus caudatus Species

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 26(3).
[doi:10.3390/ijms26031150]

2024

García-Almodóvar, V, Ovejero-Paredes, K, Díaz-García, D, Méndez-Arriaga, JM, Prashar, S, Filice, M, Gómez-Ruiz, S (2024).

Albumin-Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple-Negative Breast Cancer

Advanced Therapeutics. Article. 7(10).
[doi:10.1002/adtp.202400114]

Lorca, M, Muscia, GC, Pérez-Benavente, S, Bautista, JM, Acosta, A, González, C, Sabadini, G, Mella, J, Asis, SE, Mellado, M (2024).

2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of Plasmodium falciparum: An In Silico Approach with Experimental Validation

Pharmaceuticals. Article. 17(7).
[doi:10.3390/ph17070889]

Abad, P, Coronado, M, Vincelle-Nieto, A, Pérez-Benavente, S, Fobil, JN, Puyet, A, Diez, A, Reyes-Palomares, A, Azcárate, IG, Bautista, JM (2024).

Shotgun Characterization of the Circulating IgM Antigenome of an Infectious Pathogen by Immunocapture-LC-MS/MS from Dried Serum Spots

JOURNAL OF PROTEOME RESEARCH. Article. 23(2):633-643.
[doi:10.1021/acs.jproteome.3c00439]

2023

Kamali AN, Bautista JM, Eisenhut M, Hamedifar H (2023).

Immune checkpoints and cancer immunotherapies: insights into newly potential receptors and ligands.

Therapeutic Advances In Vaccines And Immunotherapy. Article. 11.
[doi:10.1177/25151355231192043]

Helegbe GK, Wemakor A, Ameade EPK, Anabire NG, Anaba F, Bautista JM, Zorn BG (2023).

Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases.

Journal of Clinical Medicine. Article. 12(15).
[doi:10.3390/jcm12155085]

Sánchez-Jaut, S, Pérez-Benavente, S, Abad, P, Méndez-Cuadro, D, Puyet, A, Diez, A, Galicia-Poblet, G, Gómez-Domínguez, E, Moran-Jiménez, MJ, Bautista, JM, Azcárate, IG (2023).

Protein Susceptibility to Peroxidation by 4-Hydroxynonenal in Hereditary Hemochromatosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 24(3).
[doi:10.3390/ijms24032922]

Cabrera-Muñoz A, Sierra-Gómez Y, Covaleda-Cortés G, Reytor ML, González-González Y, Bautista JM, Avilés FX, Alonso-Del-Rivero M (2023).

Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita peloronta with Anti-Plasmodium falciparum Activity.

Marine Drugs. Article. 21(2).
[doi:10.3390/md21020094]

2022

Munoz-Hernando, L, Oliver-Perez, R, Bravo-Violeta, V, Olloqui, A, Parte-Izquierdo, B, Almansa-Gonzalez, C, Bermejo-Martinez, R, Miguel, ABBD, Diez, A, Seoane-Ruiz, JM, Parrilla-Rubio, L, Tejerizo-Garcia, A (2022).

Prevalence of Anal High-Risk Human Papilloma Virus Infection and Abnormal Anal Cytology among Women Living with HIV

Journal of Personalized Medicine. Article. 12(11).
[doi:10.3390/jpm12111778]

Abad, P, Marin-Garcia, P, Heras, M, Fobil, JN, Hutchful, AG, Diez, A, Puyet, A, Reyes-Palomares, A, Azcarate, IG, Bautista, JM (2022).

Microscopic and submicroscopic infection by Plasmodium falciparum: Immunoglobulin M and A profiles as markers of intensity and exposure

Frontiers in Cellular and Infection Microbiology. Article. 12:934321-934321.
[doi:10.3389/fcimb.2022.934321]

Rodriguez-Munoz, D, Sanchez, A, Perez-Benavente, S, Contreras-Jurado, C, Montero-Pedrazuela, A, Toledo-Castillo, M, Gutierrez-Hernandez, M, Rodrigues-Diez, R, Folgueira, C, Briones, AM, Sabio, G, Monedero-Cobeta, I, Chaves-Coira I, Castejon, D, Fernandez-Valle, E, Regadera, J, Bautista, JM, Aranda, A, Alemany, S (2022).

Hypothyroidism confers tolerance to cerebral malaria.

Science Advances. Article. 8(14).
[doi:10.1126/sciadv.abj7110]

2021

Thomson-Luque R, Bautista JM (2021).

Home Sweet Home: Plasmodium vivax-Infected Reticulocytes-The Younger the Better?

Frontiers in Cellular and Infection Microbiology. Review. 11:675156-675156.
[doi:10.3389/fcimb.2021.675156]

Kamali, AN, Zian, Z, Bautista, JM, Hamedifar, H, Hossein-Khannazer, N, Hosseinzadeh, R, Yazdani, R, Azizi, G (2021).

The Potential Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Epilepsy Pathogenesis.

Endocrine Metabolic & Immune Disorders-Drug Targets. Article. 21(10):1760-1774.
[doi:10.2174/1871530320999201116200940]

2020

Azcárate, IG, Marín-García, P, Abad, P, Pérez-Benavente, S, Paz-Artal, E, Reche, PA, Fobil, JN, Rubio, JM, Diez, A, Puyet, A, Bautista, JM (2020).

Plasmodium falciparum immunodominant IgG epitopes in subclinical malaria.

Scientific Reports. Article. 10(1):9398-9398.
[doi:10.1038/s41598-020-66384-0]

Tejerizo-Garcia, A, Olloqui, A, Lopez, G, Alvarez-Conejo, C, Caso-Maestro, O, Diez, A (2020).

Step-by-step total pelviperitonectomy with modified posterior pelvic exenteration.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. Editorial Material. 30(4):558-558.
[doi:10.1136/ijgc-2019-000984]

2019

Rodriguez-Garcia, A, Morales, ML, Garrido-Garcia, V, Garcia-Baquero, I, Leivas, A, Carreño-Tarragona G, Sanchez, R, Arenas, A, Cedena, T, Ayala, RM, Bautista, JM, Martinez-Lopez, J, Linares, M (2019).

Protein Carbonylation in Patients with Myelodysplastic Syndrome: An Opportunity for Deferasirox Therapy.

Antioxidants. Article. 8(11).
[doi:10.3390/antiox8110508]

González LM, Estrada K, Grande R, Jiménez-Jacinto V, Vega-Alvarado L, Sevilla E, Barrera J, Cuesta I, Zaballos Á, Bautista JM, Lobo CA, Sánchez-Flores A, Montero E (2019).

Comparative and functional genomics of the protozoan parasite Babesia divergens highlighting the invasion and egress processes.

PLOS NEGLECT TROP D. Article. 13(8).
[doi:10.1371/journal.pntd.0007680]

Kamali, AN, Noorbakhsh, SM, Hamedifar, H, Jadidi-Niaragh, F, Yazdani, R, Bautista, JM, Azizi, G (2019).

A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders

MOLECULAR IMMUNOLOGY. Article. 105:107-115.
[doi:10.1016/j.molimm.2018.11.015]

de Mendoza, C, Bautista, JM, Perez-Benavente, S, Kwawu, R, Fobil, J, Soriano, V, Diez, A (2019).

Screening for retroviruses and hepatitis viruses using dried blood spots reveals a high prevalence of occult hepatitis B in Ghana.

Therapeutic Advances in Infectious Disease. Article. 6.
[doi:10.1177/2049936119851464]

2018

Royo, S, Schirmeister, T, Kaiser, M, Jung, S, Rodriguez, S, Bautista, JM, Gonzalez, FV (2018).

Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates

BIOORGANIC & MEDICINAL CHEMISTRY. Article. 26(16):4624-4634.
[doi:10.1016/j.bmc.2018.07.015]

Alencar, N, Sola, I, Linares, M, Juarez-Jimenez, J, Pont, C, Viayna, A, Vilchez, D, Sampedro, C, Abad, P, Perez-Benavente, S, Lameira, J, Bautista, JM, Muñoz-Torrero D, Luque, FJ (2018).

First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. Article. 146:108-122.
[doi:10.1016/j.ejmech.2018.01.044]

Ortiz-Ruiz, A, Postigo, M, Gil-Casanova, S, Cuadrado, D, Bautista, JM, Rubio, JM, Luengo-Oroz, M, Linares, M (2018).

Plasmodium species differentiation by non-expert on-line volunteers for remote malaria field diagnosis

MALARIA JOURNAL. Article. 17(1):54-54.
[doi:10.1186/s12936-018-2194-8]

2017

Azcárate IG, Sánchez-Jaut S, Marín-García P, Linares M, Pérez-Benavente S, García-Sánchez M, Uceda J, Kamali AN, Morán-Jiménez MJ, Puyet A, Diez A, Bautista JM (2017).

Iron supplementation in mouse expands cellular innate defences in spleen; and defers lethal malaria infection

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. Article. 1863(12):3049-3059.
[doi:10.1016/j.bbadis.2017.09.027]

2016

Arsuaga, Marta, Gonzalez, Luis M., Lobo, Cheryl A., de la Calle, Fernando, Bautista, Jose M., Azcarate, Isabel G., Puente, Sabino, Montero, Estrella (2016).

First Report of Babesia microti-Caused Babesiosis in Spain

VECTOR-BORNE AND ZOONOTIC DISEASES. Article. 16(10):677-679.
[doi:10.1089/vbz.2016.1946]

2015

Azcárate IG, Marín-García P, Pérez-Benavente S, Diez A, Puyet A, Bautista JM (2015).

Early and late B cell immune responses in lethal and self-cured rodent malaria

IMMUNOBIOLOGY. Article. 220(5):684-691.
[doi:10.1016/j.imbio.2014.11.010]

Kamali, Ali N., Marin-Garcia, Patricia, Azcarate, Isabel G., Puyet, Antonio, Diez, Amalia, Bautista, Jose M. (2015).

Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity

Journal of Immunology Research. Article. 2015:723946-723946.
[doi:10.1155/2015/723946]

2014

Novoa EM, Camacho N, Tor A, Wilkinson B, Moss S, Marín-García P, Azcárate IG, Bautista JM, Mirando AC, Francklyn CS, Varon S, Royo M, Cortés A, Ribas de Pouplana L (2014).

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Article. 111(51):5508-5517.
[doi:10.1073/pnas.1405994111]

Bautista JM (2014).

Epigenetic therapy reprograms hereditary disease

BLOOD. Editorial Material. 124(1):7-8.
[doi:10.1182/blood-2014-05-575423]

Bautista JM, Marín-García P, Diez A, Azcárate IG, Puyet A (2014).

Malaria proteomics: Insights into the parasite-host interactions in the pathogenic space

Journal of Proteomics. Review. 97:107-125.
[doi:10.1016/j.jprot.2013.10.011]

Azcarate, Isabel G., Marin-Garcia, Patricia, Kamali, Ali N., Perez-Benavente, Susana, Puyet, Antonio, Diez, Amalia, Bautista, Jose M. (2014).

Differential Immune Response Associated to Malaria Outcome Is Detectable in Peripheral Blood following Plasmodium yoelii Infection in Mice

PLoS One. Article. 9(1).
[doi:10.1371/journal.pone.0085664]

2013

Linares M, Marín-García P, Martínez-Chacón G, Pérez-Benavente S, Puyet A, Diez A, Bautista JM (2013).

Glutathione peroxidase contributes with heme oxygenase-1 to redox balance in mouse brain during the course of cerebral malaria

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. Article. 1832(12):2009-2018.
[doi:10.1016/j.bbadis.2013.07.010]

Zimmerman, Tahl, Moneriz, Carlos, Diez, Amalia, Manuel Bautista, Jose, Gomez del Pulgar, Teresa, Cebrian, Arancha, Carlos Lacal, Juan (2013).

Antiplasmodial Activity and Mechanism of Action of RSM-932A, a Promising Synergistic Inhibitor of Plasmodium falciparum Choline Kinase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. Article. 57(12):5878-5888.
[doi:10.1128/AAC.00920-13]

McDonagh, Ellen M., Bautista, Jose M., Youngster, Ilan, Altman, Russ B., Klein, Teri E. (2013).

PharmGKB summary: methylene blue pathway

Pharmacogenetics and Genomics. Article. 23(9):498-508.
[doi:10.1097/FPC.0b013e32836498f4]

Azcárate IG, Marín-García P, Camacho N, Pérez-Benavente S, Puyet A, Diez A, Ribas de Pouplana L, Bautista JM (2013).

Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin

BRITISH JOURNAL OF PHARMACOLOGY. Article. 169(3):645-658.
[doi:10.1111/bph.12156]

Castro, E., Marin-Garcia, P., Bautista, J. M., Montero, E., Rubio, J. M. (2013).

THE EFFICACY OF UVC PATHOGEN INACTIVATION ON THE REDUCTION OF PLASMODIUM FALCIPARUM IN BUFFY COAT DERIVED PLATELETS

VOX SANGUINIS. Meeting Abstract. 105(1, SI):133-134.

Hoen, Rob, Maria Novoa, Eva, Lopez, Alba, Camacho, Noelia, Cubells, Laia, Vieira, Pedro, Santos, Manuel, Marin-Garcia, Patricia, Maria Bautista, Jose, Cortes, Alfred, Ribas de Pouplana, Lluis, Royo, Miriam (2013).

Selective Inhibition of an Apicoplastic Aminoacyl-tRNA Synthetase from Plasmodium falciparum

CHEMBIOCHEM. Article. 14(4):499-509.
[doi:10.1002/cbic.201200620]