Regenerative Medicine |

Publications

2023

Gramignoli, R, Hofmann, N, Agudo-Barriuso, M, Antica, M, Flores, A, Girandon, L, Kerdjoudj, H, Navakauskiene, R, Schiavi, J, Scholz, H, Shablii, V, Lafarge, X, Nicolas, FJ, Gindraux, F (2023).

Expert Revision of Key Elements for Clinical-Grade Production and Qualification of Perinatal Derivatives

STEM CELLS TRANSLATIONAL MEDICINE. Review. 13(1):14-29.
[doi:10.1093/stcltm/szad068]

Cruz-Utrilla, A, Martín, EPG, Pérez, LD, Curiel, AR, Quezada, A, López, AD, Vicent, L, Asenjo, RM, Hinojosa, W, Eixerés, A, Acebal, LF, Galindo, M, Ynsaurriaga, FA, Escribano-Subias, P, Bueno, H (2023).

ECMO in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension as a bridge to therapy

KARDIOLOGIA POLSKA. Editorial Material. 81(5):500-504.
[doi:10.33963/KP.a2023.0055]

de la Torre, P, Pérez-Lorenzo, MJ, Alcázar-Garrido, A, Collado, J, Martínez-López, M, Forcén, L, Masero-Casasola, AR, García, A, Gutiérrez-Vélez, MC, Medina-Polo, J, Muñoz, E, Flores, AI (2023).

Perinatal mesenchymal stromal cells of the human decidua restore continence in rats with stress urinary incontinence induced by simulated birth trauma and regulate senescence of fibroblasts from women with stress urinary incontinence.

Frontiers In Cell And Developmental Biology. Article. 10:1033080-1033080.
[doi:10.3389/fcell.2022.1033080]

2022

Illán Ramos M, Prieto Tato LM, Guillén Martín S, Navarro Gómez ML, Escosa García L, Roa Francia MÁ, Beceiro Mosquera J, Olabarrieta Arnal I, Muñoz Gálligo E, Viñuela Benéitez MC, Regidor Sáez FJ, Mazariegos Orellana D, Fuentes Ferrer M, Berzosa Sánchez A, Callejas Caballero I, Ramos Amador JT (2022).

Clinical and Epidemiologic Characteristics of a Cohort of HIV-Infected Mother-Infant Pairs During 21 Years.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. Article. 91(5):479-484.
[doi:10.1097/QAI.0000000000003085]

Nogueira López J, Prieto-Tato L, Escosa-García L, Bernardino JI, Muñoz E, Díez C, Carrasco I, Ryan P, Guillén-Martín S, Ramos-Amador JT, Navarro ML, Holguín A, Sainz T (2022).

Pregnancy Outcomes Among Perinatally HIV-Infected Women in Spain.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. Article. 91(4):373-380.
[doi:10.1097/QAI.0000000000003070]

Flores AI, Pipino C, Jerman UD, Liarte S, Gindraux F, Kreft ME, Nicolas FJ, Pandolfi A, Tratnjek L, Giebel B, Pozzobon M, Silini AR, Parolini O, Eissner G, Lang-Olip I (2022).

Perinatal derivatives: How to best characterize their multimodal functions in vitro. Part C: Inflammation, angiogenesis, and wound healing.

Frontiers in Bioengineering and Biotechnology. Review. 10:965006-965006.
[doi:10.3389/fbioe.2022.965006]

Barbero P, Mugüerza L, Herraiz I, García Burguillo A, San Juan R, Forcén L, Mejía I, Batllori E, Montañez MD, Vallejo P, Villar O, García Alcazar D, Galindo A (2022).

SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. Article. 35(14):1-7.
[doi:10.1080/14767058.2020.1793320]

Pingarrón Santofímia C, Lafuente González P, Guitiérrez Vélez MDC, Calvente Aguilar V, Poyo Torcal S, Terol Sánchez P, Palacios S (2022).

Long-term use of ospemifene in clinical practice for vulvo-vaginal atrophy: end results at 12 months of follow-up.

GYNECOLOGICAL ENDOCRINOLOGY. Article. 38(7):577-582.
[doi:10.1080/09513590.2022.2083103]

Álvarez Bartolomé A, Abdallah Kassab NA, Cruz Melguizo S, de la Cruz Conty ML, Forcen Acebal L, Abascal Saiz A, Pintado Recarte P, Martinez Varea A, Cerrillos Gonzalez L, García Fernández J, Martínez Pérez O (2022).

Critical Care in SARS-CoV-2 Infected Pregnant Women: A Prospective Multicenter Study.

Biomedicines. Article. 10(2).
[doi:10.3390/biomedicines10020475]

2021

Paris JL, de la Torre P, Flores AI (2021).

New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies.

Pharmaceutics. Review. 13(12).
[doi:10.3390/pharmaceutics13122149]

Antolin, EM, Molanes, JRB, Conty, MLD, Pardilla, MBE, Martin, MDG, Bueno, JAS, Acebal, LF, Recarte, PP, Bartolome, AA, Cendan, JPM, Martinez-Perez, O (2021).

SARS-CoV-2 Infection and C-Section: A Prospective Observational Study

Viruses-Basel. Article. 13(11).
[doi:10.3390/v13112330]

Serrano, LJ, de la Torre, P, Liras, A, Flores, AI (2021).

Cell therapy for factor V deficiency: An approach based on human decidua mesenchymal stem cells

BIOMEDICINE & PHARMACOTHERAPY. Article. 142.
[doi:10.1016/j.biopha.2021.112059]

Cobo T, Aldecoa V, Bartha JL, Bugatto F, Paz Carrillo-Badillo M, Comas C, Diago-Almeda V, Ferrero S, Goya M, Herraiz I, Martí-Malgosa L, Olivella A, Paulés C, Vives À, Figueras F, Palacio M, Gratacós E, OPTIM-PTL group (2021).

Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study).

BMJ OPEN. Article. 11(9).
[doi:10.1136/bmjopen-2021-054711]

Engels Calvo V, Cruz Melguizo S, Abascal-Saiz A, Forcén Acebal L, Sánchez-Migallón A, Pintado Recarte P, Cuenca Marín C, Marcos Puig B, Del Barrio Fernández PG, Nieto Velasco O, de la Cruz Conty ML, Martínez-Perez O, Spanish Obstetric Emergency Group (2021).

Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study.

FERTILITY AND STERILITY. Article. 116(3):731-740.
[doi:10.1016/j.fertnstert.2021.04.005]

Vouga, M, Favre, G, Pomar, L, Acebal, LF, Abascal-Saiz, A, Hernandez, MRV, Hcini, N, Lambert, V, Carles, G, Sichitiu, J, Salomon, L, Stirnemann, J, Ville, Y, de Tejada, BM, Gonce, A, Castillo, K, Solsona, EG, Trigo, L, Cleary, B, Geary, M, Bartels, H, Malone, F, Higgins, M, Keating, N, Knowles, S, Poncelet, C, Surita, F, Borrelli, C, Luz, AG, Fuenzalida, J, Carvajal, J, Canales, MG, Hernandez, O, Grechukhina, O, Ko, AI, Reddy, U, Figueiredo, R, Moucho, M, Pinto, P, De Luca, C, De Santis, M, de Campos, DA, Martins, I, Garabedian, C, Subtil, D, Bohrer, B, Oppermann, MLD, OsorioWender, MC, Sanseverino, MTV, Giugliani, C, Friedrich, L, Scherer, MH, Mottet, N, Ducarme, G, Pelerin, H, Moreau, C, Breton, B, Quibel, T, Rozenberg, P, Giannoni, E, Granado, C, Monod, C, Mueller, D, Hoesli, I, Bassler, D, Heldstab, S, Kolble, NO, Sentilhes, L, Charvet, M, Deprest, J, Richter, J, Van der Veeken, L, Eggel-Hort, B, Plantefeve, G, Derouich, M, Calvache, AJN, Hecher, K, Hadar, E, Haratz, KK, Amikam, U, Malinger, G, Maymon, R, Yogev, Y, Schafer, L, Toussaint, A, Rossier, MC, De Sa, RM, Grawe, C, Aebi-Popp, K, Raio, L, Surbek, D, Bockenhof, P, Strizek, B, Kaufmann, M, Bloch, A, Boulvain, M, Johann, S, Heldstab, S, Bernasconi, M, Grant, G, Feki, A, Brochut, ACM, Giral, M, Sedille, L, Papadia, A, Brugger, RC, Weber, B, Fischer, T, Kahlert, C, Saines, KN, Cambou, M, Kanellos, P, Chen, X, Yin, MZ, Haessig, A, Ackermann, S, Baud, D, Panchaud, A (2021).

Maternal outcomes and risk factors for COVID-19 severity among pregnant women

SCIENTIFIC REPORTS. Article. 11(1).
[doi:10.1038/s41598-021-92357-y]

Martinez-Perez O, Rodriguez, PP, Hernandez, MM, Pardilla, MBE, Perez Perez N, Hernandez, MRV, Yarza, AV, Velasco, ON, Fernandez, PGD, Acebal, LF, Lago, CMO, Varea, AM, Abellana, BM, Arana, MS, Ricoy, LF, Diago, CM, Freire, MJJ, Alvarez-Mallo, MA, Pedraz, CC, Mateu, OA, Heredia, CL, de Alva, JCW, Vega, RB, Badia, MM, Colomo, CA, Munoz, AS, Alicart, LP, Saiz, RA, Rodriguez, ML, Lopez, MDB, Casbas, MRM, Ruiz, OV, Antolin, EM, Valera, MJN, Fernandez Fernandez C, Navarra, AT, Garcia, AMC, Luque, CB, Perez, SS, Abasolo, IG, Garcia, JA, Gonzalez, MT, Prieto, AP, Serna, RO, Martin, MDG, Coello, MC, Perez, EF, Aguilar, AC, Conty, MLD, Bueno, JAS, Spanish Obstet Emergency (2021).

The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis

BMC PREGNANCY AND CHILDBIRTH. Article. 21(1):273-273.
[doi:10.1186/s12884-021-03742-4]

de la Torre, P, Paris, JL, Fernández-de la Torre, M, Vallet-Regí, M, Flores, AI (2021).

Endostatin Genetically Engineered Placental Mesenchymal Stromal Cells Carrying Doxorubicin-Loaded Mesoporous Silica Nanoparticles for Combined Chemo- and Antiangiogenic Therapy

Pharmaceutics. Article. 13(2).
[doi:10.3390/pharmaceutics13020244]

de la Torre P, Fernández-de la Torre M, Flores AI (2021).

Premature senescence of placental decidua cells as a possible cause of miscarriage produced by mycophenolic acid

JOURNAL OF BIOMEDICAL SCIENCE. Article. 28(1):3-3.
[doi:10.1186/s12929-020-00704-4]

Cruz-Lemini M, Ferriols Perez E, de la Cruz Conty ML, Caño Aguilar A, Encinas Pardilla MB, Prats Rodríguez P, Muner Hernando M, Forcen Acebal L, Pintado Recarte P, Medina Mallen MDC, Perez Perez N, Canet Rodriguez J, Villalba Yarza A, Nieto Velasco O, Del Barrio Fernandez PG, Orizales Lago CM, Marcos Puig B, Muñoz Abellana B, Fuentes Ricoy L, Rodriguez Vicente A, Janeiro Freire MJ, Alferez Alvarez-Mallo M, Casanova Pedraz C, Alomar Mateu O, Lesmes Heredia C, Wizner de Alva JC, Posadas San Juan A, Macia Badia M, Alvarez Colomo C, Sanchez Muñoz A, Pratcorona Alicart L, Alonso Saiz R, Lopez Rodriguez M, Barbancho Lopez MC, Meca Casbas MR, Vaquerizo Ruiz O, Moran Antolin E, Nuñez Valera MJ, Fernandez Fernandez C, Tubau Navarra A, Cano Garcia AM, Soldevilla Perez S, Gattaca Abasolo I, Adanez Garcia J, Puertas Prieto A, Ostos Serna R, Guadix Martin MDP, Catalina Coello M, Espuelas Malon S, Sainz Bueno JA, Granell Escobar MR, Cruz Melguizo S, Martinez Perez O, On Behalf Of The Spanish Obstetric Emergency Group (2021).

Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women

Viruses-Basel. Article. 13(1).
[doi:10.3390/v13010112]

de la Torre, P, Flores, AI (2021).

Current Status and Future Prospects of Perinatal Stem Cells

Genes. Review. 12(1).
[doi:10.3390/genes12010006]

2020

Illán Ramos M, Mazariegos Orellana D, Prieto Tato LM, Navarro Gómez ML, Muñoz Gálligo E, Ramos Amador JT (2020).

Effectiveness and safety of integrase inhibitors in HIV-infected pregnant women followed up in the Madrid Cohort.

MEDICINA CLINICA. Article. 155(10):441-444.
[doi:10.1016/j.medcli.2020.01.036]

Herraiz, I, Folgueira, D, Villalaín, C, Forcén, L, Delgado, R, Galindo, A (2020).

Universal screening for SARS-CoV-2 before labor admission during Covid-19 pandemic in Madrid.

JOURNAL OF PERINATAL MEDICINE. Article. 48(9):981-984.
[doi:10.1515/jpm-2020-0236]

San-Juan R, Barbero P, Fernández-Ruiz M, López-Medrano F, Lizasoáin M, Hernández-Jiménez P, Silva JT, Ruiz-Ruigómez M, Corbella L, Rodríguez-Goncer I, Folgueira MD, Lalueza A, Batllori E, Mejía I, Forcén L, Lumbreras C, García-Burguillo A, Galindo A, Aguado JM (2020).

Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.

Eclinicalmedicine. Article. 23:100407-100407.
[doi:10.1016/j.eclinm.2020.100407]

de la Torre, P, Pérez-Lorenzo, MJ, Alcázar-Garrido, A, Flores, AI (2020).

Cell-Based Nanoparticles Delivery Systems for Targeted Cancer Therapy: Lessons from Anti-Angiogenesis Treatments.

Molecules. Review. 25(3).
[doi:10.3390/molecules25030715]

Domínguez-Rodríguez, S, Prieto, L, Fernández McPhee C, Illán-Ramos M, Beceiro, J, Escosa, L, Munoz, E, Olabarrieta, I, Regidor, FJ, Roa, MA, Viñuela Beneítez MDC, Guillén, S, Navarro-Gómez, ML, Ramos Amador JT, Madrid Cohort of HIV-infected mother-infant pairs (2020).

Perinatal HCV Transmission Rate in HIV/HCV Coinfected women with access to ART in Madrid, Spain.

PLOS ONE. Article. 15(4).
[doi:10.1371/journal.pone.0230109]

2019

Calvo, AC, Cibreiro, GA, Merino, PT, Roy, JF, Galiana, A, Rufián, AJ, Cano, JM, Martín, MA, Moreno, L, Larrodé, P, Vázquez, PC, Galán, L, Mora, J, Muñoz-Blanco JL, Muñoz MJ, Zaragoza, P, Pegoraro, E, Sorarù, G, Mora, M, Lunetta, C, Penco, S, Tarlarini, C, Esteban, J, Osta, R, Redondo, AG (2019).

Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis.

Aging and Disease. Article. 10(2):278-292.
[doi:10.14336/AD.2018.0917]

Ortiz-Bautista C, Lopez-Gude MJ, Grande Garcia J, Perez-Vela JL, Perez-Gonzalez V, Escribano-Subias P (2019).

Extracorporeal Membrane Oxygenation Support During Pregnancy in Pulmonary Veno-occlusive Disease

REVISTA ESPANOLA DE CARDIOLOGIA. Letter. 72(2):174-175.
[doi:10.1016/j.recesp.2017.12.018]

Paris, JL, de la Torre, P, Cabanas, MV, Manzano, M, Flores, AI, Vallet-Regí, M (2019).

Suicide-gene transfection of tumor-tropic placental stem cells employing ultrasound-responsive nanoparticles

ACTA BIOMATERIALIA. Article. 83:372-378.
[doi:10.1016/j.actbio.2018.11.006]

2018

Polo, R, Palacios, R, Andreu, A, Blanco, BJL, Blanco, JR, Camino, X, Castillo, O, Curran, A, del Romero, J, Diaz, A, Fernandez, C, Gil, L, Tome, MG, Hidalgo, C, de Munain, JL, Margall, N, Navarro, M, Otero, L, Perez-Molina, JA, Prieto, L, Munoz, E, Puerta, T, Pueyo, I, Vall, M, Vazquez, F, Viciana, P, Vinuela, MC, Barbera, MJ, Natl AIDS Plan, Spanish Acad Dermatology, Spanish Soc Pediat Infect SEIP (2018).

Consensus document on the diagnosis and treatment of sexually transmitted diseases in adults, children and adolescents

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA. Article. 36(9):576-585.
[doi:10.1016/j.eimc.2017.06.004]

Serrano, LJ, Canete, A, Garcia-Leal, T, Tomas-Gallardo, L, Flores, AI, de la Torre, P, Liras, A, Sanchez, MJ (2018).

Searching for a Cell-Based Therapeutic Tool for Haemophilia A within the Embryonic/Foetal Liver and the Aorta-Gonads-Mesonephros Region

THROMBOSIS AND HAEMOSTASIS. Article. 118(8):1370-1381.
[doi:10.1055/s-0038-1661351]

2017

Prieto, LM, McPhee, CF, Rojas, P, Mazariegos, D, Munoz, E, Mellado, MJ, Holguin, A, Navarro, ML, Gonzalez-Tome, M, Ramos, JT, Madrid Cohort HIV-Infected Mother (2017).

Pregnancy outcomes in perinatally HIV-infected young women in Madrid,; Spain: 2000-2015

PLOS ONE. Article. 12(8).
[doi:10.1371/journal.pone.0183558]

Paris JL, de la Torre P, Victoria Cabañas M, Manzano M, Grau M, Flores AI, Vallet-Regí M (2017).

Vectorization of ultrasound-responsive nanoparticles in placental; mesenchymal stem cells for cancer therapy

Nanoscale. Article. 9(17):5528-5537.
[doi:10.1039/c7nr01070b]

2016

Olmedillas Lopez, Susana, Garcia-Arranz, Mariano, Garcia-Olmo, Damian, Liras, Antonio (2016).

Preliminary study on non-viral transfection of F9 (factor IX) gene by nucleofection in hum an adipose-derived mesenchymal stem cells

PeerJ. Article. 4.
[doi:10.7717/peerj.1907]

Bravo, Beatriz, Gallego, Marta I., Flores, Ana I., Bornstein, Rafael, Puente-Bedia, Alba, Hernandez, Javier, de la Torre, Paz, Garcia-Zaragoza, Elena, Perez-Tavarez, Raquel, Grande, Jesus, Ballester, Alicia, Ballester, Sara (2016).

Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis.

STEM CELL RESEARCH & THERAPY. Article. 7:43-43.
[doi:10.1186/s13287-016-0304-5]

Paris JL, Torre P, Manzano M, Cabañas MV, Flores AI, Vallet-Regí M (2016).

Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors.

ACTA BIOMATERIALIA. Article. 33:275-282.
[doi:10.1016/j.actbio.2016.01.017]

Gonzalez C, Bonilla S, Flores AI, Cano E, Liste I (2016).

An Update on Human Stem Cell-Based Therapy in Parkinson's Disease.

CURR STEM CELL RES T. Article. 11(7):561-568.
[doi:10.2174/1574888X10666150531172612]

2015

Liras A (2015).

Biological therapies for inherited diseases: social and bioethical considerations. Hemophilia as an example

EXPERT OPINION ON BIOLOGICAL THERAPY. Review. 15(5):713-722.
[doi:10.1517/14712598.2015.1029451]

Flores AI, Gómez-Gómez GJ, Masedo-González Á, Martínez-Montiel MP (2015).

Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?

World journal of stem cells. Review. 7(2):343-351.
[doi:10.4252/wjsc.v7.i2.343]

2014

Cerrada A, de la Torre P, Grande J, Haller T, Flores AI, Pérez-Gil J (2014).

Human decidua-derived mesenchymal stem cells differentiate into functional alveolar type II-like cells that synthesize and secrete pulmonary surfactant complexes.

PLOS ONE. Article. 9(10).
[doi:10.1371/journal.pone.0110195]

del Pilar Martinez-Montiel, Maria, Jesus Gomez-Gomez, Gonzalo, Isabel Flores, Ana (2014).

Therapy with stem cells in inflammatory bowel disease

WORLD JOURNAL OF GASTROENTEROLOGY. Article. 20(5):1211-1227.
[doi:10.3748/wjg.v20.i5.1211]

2013

Torrecilla, Jose S., Cancilla, John C., Matute, Gemma, Diaz-Rodriguez, Pablo, Flores, Ana I. (2013).

Self-organizing maps based on chaotic parameters to detect adulterations of extra virgin olive oil with inferior edible oils

JOURNAL OF FOOD ENGINEERING. Article. 118(4):400-405.
[doi:10.1016/j.jfoodeng.2013.04.029]

Cerrada, A., Haller, T., Flores, A. I., Perez-Gil, J. (2013).

Biophysics of a novel surfactant secreted from stem cells differentiated into pneumocyte-like cells

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. Meeting Abstract. 42(1):119-119.

Vegh, I., Grau, M., Gracia, M., Grande, J., de la Torre, P., Flores, A. I. (2013).

Decidua mesenchymal stem cells migrated toward mammary tumors in vitro and in vivo affecting tumor growth and tumor development

CANCER GENE THERAPY. Article. 20(1):8-16.
[doi:10.1038/cgt.2012.71]

2012

Bornstein, Rafael, Macias, Maria I., de la Torre, Paz, Grande, Jesus, Flores, Ana I. (2012).

Human decidua-derived mesenchymal stromal cells differentiate into hepatic-like cells and form functional three-dimensional structures

CYTOTHERAPY. Article. 14(10):1182-1192.
[doi:10.3109/14653249.2012.706706]

Cerrada, A., Haller, T., Flores, A. I., Gil, J. P. (2012).

Cellular models for the study of pulmonary surfactant biogenesis and functional mechanisms

FEBS JOURNAL. Meeting Abstract. 279(1, SI):121-121.

Vela, A., Galan, L., Valencia, C., de la Torre, P., Cuadrado, M. L., Esteban, J., Guerrero, A., Garcia-Redondo, A., Matias-Guiu, J. (2012).

SOD1-N196 mutation in a family with amyotrophic lateral sclerosis

NEUROLOGIA. Article. 27(1):11-15.
[doi:10.1016/j.nrl.2011.02.011]

2010

Macias, Maria I., Grande, Jesus, Moreno, Ana, Dominguez, Irene, Bornstein, Rafael, Flores, Ana I. (2010).

Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. Article. 203(5).
[doi:10.1016/j.ajog.2010.06.045]