Investigación Traslacional en Leishmaniosis |

Publicaciones

2024

Garcia-Juan, Marta, Ordonez-Gutierrez, Lara, Wandosell, Francisco (2024).

Clearance of ß-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes

Glia. Article. 72(3):588-606.
[doi:10.1002/glia.24492]

2023

Alunda JM (2023).

Antileishmanial and Antitrypanosomes Drugs for the Current Century.

Microorganisms. Editorial Material. 12(1).
[doi:10.3390/microorganisms12010043]

Carrero, L, Antequera, D, Alcalde, I, Megias, D, Ordoñez-Gutierrez, L, Gutierrez, C, Merayo-Lloves, J, Wandosell, F, Municio, C, Carro, E (2023).

Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina

International Journal Of Molecular Sciences. Article. 24(21).
[doi:10.3390/ijms242115679]

Mateo M, Montoya A, Bailo B, Köster PC, Dashti A, Hernández-Castro C, Saugar JM, Matas P, Xiao L, Carmena D (2023).

Prevalence and public health relevance of enteric parasites in domestic dogs and cats in the region of Madrid (Spain) with an emphasis on Giardia duodenalis and Cryptosporidium sp.

Veterinary Medicine and Science. Article. 9(6):2542-2558.
[doi:10.1002/vms3.1270]

Roussaki M, Magoulas GE, Fotopoulou T, Santarem N, Barrias E, Pöhner I, Luelmo S, Afroudakis P, Georgikopoulou K, Nevado PT, Eick J, Bifeld E, Corral MJ, Jiménez-Antón MD, Ellinger B, Kuzikov M, Fragiadaki I, Scoulica E, Gul S, Clos J, Prousis KC, Torrado JJ, Alunda JM, Wade RC, de Souza W, Cordeiro da Silva A, Calogeropoulou T (2023).

Design, synthesis and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids.

BIOORGANIC CHEMISTRY. Article. 138:106615-106615.
[doi:10.1016/j.bioorg.2023.106615]

Azami-Conesa I, Pérez-Moreno P, Matas Méndez P, Sansano-Maestre J, González F, Mateo Barrientos M, Gómez-Muñoz MT (2023).

Occurrence of Leishmania infantum in Wild Mammals Admitted to Recovery Centers in Spain.

Pathogens. Article. 12(8).
[doi:10.3390/pathogens12081048]

Matas Méndez P, Fuentes Corripio I, Montoya Matute A, Bailo Barroso B, Grande Gómez R, Apruzzese Rubio A, Ponce Gordo F, Mateo Barrientos M (2023).

Prevalence of Toxoplasma gondii in Endangered Wild Felines (Felis silvestris and Lynx pardinus) in Spain.

Animals. Article. 13(15).
[doi:10.3390/ani13152488]

Robledo SM, Pérez-Silanes S, Fernández-Rubio C, Poveda A, Monzote L, González VM, Alonso-Collado P, Carrión J (2023).

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease.

Pathogens. Review. 12(7).
[doi:10.3390/pathogens12070939]

Olías-Molero AI, Botías P, Cuquerella M, García-Cantalejo J, Barcia E, Torrado S, Torrado JJ, Alunda JM (2023).

Effect of Clindamycin on Intestinal Microbiome and Miltefosine Pharmacology in Hamsters Infected with Leishmania infantum.

ANTIBIOTICS-BASEL. Article. 12(2).
[doi:10.3390/antibiotics12020362]

2022

Olías-Molero AI, Botías P, Cuquerella M, García-Cantalejo J, Barcia E, Torrado S, Torrado JJ, Alunda JM (2022).

Leishmania infantum infection does not affect the main composition of the intestinal microbiome of the Syrian hamster.

PARASITES & VECTORS. Article. 15(1):468-468.
[doi:10.1186/s13071-022-05576-1]

Buendia-Abad, M, Garcia-Palencia, P, de Pablos, LM, Alunda, JM, Osuna, A, Martin-Hernandez, R, Higes, M (2022).

First description of Lotmaria passim and Crithidia mellificae haptomonad stages in the honeybee hindgut.

INTERNATIONAL JOURNAL FOR PARASITOLOGY. Article. 52(1):65-75.
[doi:10.1016/j.ijpara.2021.06.005]

2021

Olias-Molero, AI, de la Fuente, C, Cuquerella, M, Torrado, JJ, Alunda, JM (2021).

Antileishmanial Drug Discovery and Development: Time to Reset the Model?

Microorganisms. Article. 9(12).
[doi:10.3390/microorganisms9122500]

Olias-Molero, AI, Fontan-Matilla, E, Cuquerella, M, Alunda, JM (2021).

Scientometric analysis of chemotherapy of canine leishmaniasis (2000-2020)

PARASITES & VECTORS. Article. 14(1):36-36.
[doi:10.1186/s13071-020-04544-x]

2020

Gjerde B, de la Fuente C, Alunda JM, Luzón M (2020).

Molecular characterisation of five Sarcocystis species in domestic sheep (Ovis aries) from Spain.

PARASITOLOGY RESEARCH. Article. 119(1):215-231.
[doi:10.1007/s00436-019-06504-6]

2019

Manzano, JI, Cueto-Diaz, EJ, Olias-Molero, AI, Perea, A, Herraiz, T, Torrado, JJ, Alunda, JM, Gamarro, F, Dardonville, C (2019).

Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis

JOURNAL OF MEDICINAL CHEMISTRY. Article. 62(23):10664-10675.
[doi:10.1021/acs.jmedchem.9b00998]

Olias-Molero, AI, Corral, MJ, Jimenez-Anton, MD, Alunda, JM (2019).

Early antibody response and clinical outcome in experimental canine leishmaniasis.

SCIENTIFIC REPORTS. Article. 9(1):18606-18606.
[doi:10.1038/s41598-019-55087-w]

Borsari, C, Jimenez-Anton, MD, Eick, J, Bifeld, E, Torrado, JJ, Olias-Molero, AI, Corral, MJ, Santarem, N, Baptista, C, Severi, L, Gul, S, Wolf, M, Kuzikov, M, Ellinger, B, Reinshagen, J, Witt, G, Linciano, P, Tait, A, Costantino, L, Luciani, R, Tejera Nevado P, Zander-Dinse, D, Franco, CH, Ferrari, S, Moraes, CB, Cordeiro-da-Silva, A, Ponterini, G, Clos, J, Alunda, JM, Costi, MP (2019).

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. Article. 183:111676-111676.
[doi:10.1016/j.ejmech.2019.111676]

Jimenez-Anton, MD, Grau, M, Corral, MJ, Olias-Molero, AI, Alunda, JM (2019).

Efficient infection of hamster with Leishmania donovani by retro-orbital inoculation.

Virulence. Article. 10(1):711-718.
[doi:10.1080/21505594.2019.1649587]

Gonzalez-Sanchez, ME, Ndombasi-Bokuy, M, Cuquerella, M, Alunda, JM (2019).

Immunization with recombinant rHc23 partially protects lambs against trickle infections by Haemonchus contortus

BMC VETERINARY RESEARCH. Article. 15(1):333-333.
[doi:10.1186/s12917-019-2084-5]

Borsari, C, Santarem, N, Macedo, S, Jimenez-Anton, MD, Torrado, JJ, Olias-Molero, AI, Corral, MJ, Tait, A, Ferrari, S, Costantino, L, Luciani, R, Ponterini, G, Gul, S, Kuzikov, M, Ellinger, B, Behrens, B, Reinshagen, J, Alunda, JM, Cordeiro-da-Silva, A, Costi, MP (2019).

SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent

ACS MEDICINAL CHEMISTRY LETTERS. Article. 10(4):528-533.
[doi:10.1021/acsmedchemlett.8b00565]

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S (2019).

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

SLAS Discovery. Article. 24(3):346-361.
[doi:10.1177/2472555218823171]

Jiménez-Antón MD, Grau M, Olías-Molero AI, Alunda JM (2019).

Syrian Hamster as an Advanced Experimental Model for Visceral Leishmaniasis.

Methods in Molecular Biology. Article. 1971:303-314.
[doi:10.1007/978-1-4939-9210-2_17]

2018

Jimenez-Anton, MD, Garcia-Calvo, E, Gutierrez, C, Escribano, MD, Kayali, N, Luque-Garcia, JL, Olias-Molero, AI, Corral, MJ, Costi, MP, Torrado, JJ, Alunda, JM (2018).

Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. Article. 121:281-286.
[doi:10.1016/j.ejps.2018.06.002]

Gonzalez-Sanchez, ME, Cuquerella, M, Alunda, JM (2018).

Superimposed visceral leishmanial infection aggravates response to Heligmosomoides polygyrus

PARASITES & VECTORS. Article. 11(1):404-404.
[doi:10.1186/s13071-018-2987-1]

Olias-Molero, AI, Jimenez-Anton, MD, Biedermann, D, Corral, MJ, Alunda, JM (2018).

In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and L. donovani .

Molecules. Article. 23(7).
[doi:10.3390/molecules23071560]

2017

Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Witt G, Gribbon P, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Bruno Dos Santos P, Alcântara LM, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP (2017).

Methoxylated 2 '-hydroxychalcones as antiparasitic hit compounds

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. Article. 126:1129-1135.
[doi:10.1016/j.ejmech.2016.12.017]

2016

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP (2016).

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

JOURNAL OF MEDICINAL CHEMISTRY. Article. 59(16):7598-7616.
[doi:10.1021/acs.jmedchem.6b00698]

Corral MJ, Benito-Peña E, Jiménez-Antón MD, Cuevas L, Moreno-Bondi MC, Alunda JM (2016).

Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.

PLOS NEGLECT TROP D. Article. 10(3).
[doi:10.1371/journal.pntd.0004525]

Cardoso-Martinez, Faviola, de la Rosa, Jose M., Diaz-Marrero, Ana R., Darias, Jose, D'Croz, Luis, Dolores Jimenez-Anton, M., Jesus Corral, M., Garcia, Rocio, Alunda, Jose M., Cueto, Mercedes (2016).

Oxysterols from an octocoral of the genus Gorgonia from the eastern Pacific of Panama

RSC ADVANCES. Article. 6(45):38579-38591.
[doi:10.1039/c6ra04521a]

2015

Luzón M, Domínguez-González J, Soto-Carrión AM, Alunda JM, Fuente Cde L (2015).

Sarcocystosis in Cervus elaphus: Comparison of diagnostic methods

INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE. Article. 4(3):396-400.
[doi:10.1016/j.ijppaw.2015.11.001]

Fawzi EM, González-Sánchez ME, Corral MJ, Alunda JM, Cuquerella M (2015).

Vaccination of lambs with the recombinant protein rHc23 elicits significant protection against Haemonchus contortus challenge

VETERINARY PARASITOLOGY. Article. 211(1-2):54-59.
[doi:10.1016/j.vetpar.2015.04.029]

2014

Corral MJ, Serrano DR, Moreno I, Torrado JJ, Domínguez M, Alunda JM (2014).

Efficacy of low doses of amphotericin B plus allicin against experimental visceral leishmaniasis

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. Article. 69(12):3268-3274.
[doi:10.1093/jac/dku290]

González-Sánchez E, Corral MJ, Mohamed Fawzi E, Rodríguez-Bertos A, Alunda JM, Cuquerella M (2014).

LPS and inactivated Propionibacterium acnes elicit a partially protective response in primary infections of Heligmosomoides polygyrus

VETERINARY PARASITOLOGY. Article. 203(1-2):231-236.
[doi:10.1016/j.vetpar.2014.02.026]

Fawzi EM, González-Sánchez ME, Corral MJ, Cuquerella M, Alunda JM (2014).

Vaccination of lambs against Haemonchus contortus infection with a somatic protein (Hc23) from adult helminths

INTERNATIONAL JOURNAL FOR PARASITOLOGY. Article. 44(7):429-436.
[doi:10.1016/j.ijpara.2014.02.009]