Stem Cells, Immunity and Cancer |

Publications

2026

Quintana-Castanedo, L, Maseda, R, Sánchez-Ramón, S, Butta, N, Molero-Luis, M, Crespo, MG, Buño, A, Herráiz-Gil, S, León, C, Varas, A, Fernández-Sevilla, LM, Zuluaga, P, de Lucas, R, del Río, M, Vicente, A, Escámez, MJ, Sacedón, R (2026).

Zinc as a Biomarker of Nutritional Status and Clinical Burden in Recessive Dystrophic Epidermolysis Bullosa: Implications for Preventive Monitoring

Nutrients. Article. 18(2).
[doi:10.3390/nu18020232]

2025

Ortiz-Sánchez, P, González-Soto, S, Villamizar, LH, Valencia, J, Jiménez, E, Sacedón, R, Ramírez, M, Fariñas, I, Varas, A, Fernández-Sevilla, LM, Vicente, A (2025).

Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis

CELLULAR ONCOLOGY. Article. 48(3):725-741.
[doi:10.1007/s13402-025-01043-y]

Quintana-Castanedo, L, Maseda, R, Pérez-Conde, I, Butta, N, Monzón-Manzano, E, Acuña-Butta, P, Crespo, MG, Buño-Soto, A, Jiménez, E, Valencia, J, Arriba, MC, Zuluaga, P, de Lucas, R, del Rio, M, Vicente, A, Escámez, MJ, Sacedón, R (2025).

Interplay between iron metabolism, inflammation, and EPO-ERFEhepcidin axis in RDEB-associated chronic anemia

Blood Advances. Article. 9(9):2321-2335.
[doi:10.1182/bloodadvances.2024015271]

Valencia, J, Yáñez, RM, Muntión, S, Fernández-García, M, Martín-Rufino, JD, Zapata, AG, Bueren, JA, Vicente, A, Sánchez-Guijo, F (2025).

Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity

Frontiers in Immunology. Article. 16.
[doi:10.3389/fimmu.2025.1473788]

Montero-Herradón S, García-Ceca J, Zapata AG (2025).

Thymus Ontogeny and Development.

Advances in Experimental Medicine and Biology. Article. 1471:21-49.
[doi:10.1007/978-3-031-77921-3_2]

2024

Montero-Herradón, S, García-Ceca, J, Villarejo-Torres, M, Zapata, AG (2024).

Peripheral T-cell responses of EphB2-and EphB3-deficient mice in a model of collagen-induced arthritis

CELLULAR AND MOLECULAR LIFE SCIENCES. Article. 81(1):159-159.
[doi:10.1007/s00018-024-05197-0]

Jiménez, E, Vázquez, A, González, S, Sacedón, R, Fernández-Sevilla, LM, Varas, A, Subiza, JL, Valencia, J, Vicente, A (2024).

Mucosal Bacterial Immunotherapy Attenuates the Development of Experimental Colitis by Reducing Inflammation Through the Regulation of Myeloid Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Article. 25(24).
[doi:10.3390/ijms252413629]

Quintana-Castanedo L, Sánchez-Ramón S, Maseda R, Illera N, Pérez-Conde I, Molero-Luis M, Butta N, Arias-Salgado EG, Monzón-Manzano E, Zuluaga P, Martínez-Santamaría L, Fernández-Arquero M, Llames SG, Meana Á, de Lucas R, Del Río M, Vicente Á, Escámez MJ, Sacedón R (2024).

Unveiling the value of C-reactive protein as a severity biomarker and the IL4/IL13 pathway as a therapeutic target in recessive dystrophic epidermolysis bullosa: A multiparametric cross-sectional study.

EXPERIMENTAL DERMATOLOGY. Article. 33(8).
[doi:10.1111/exd.15146]

Rodríguez-Sosa, MR, del Castillo, LM, Belarra, A, Zapata, AG, Alfaro, D (2024).

The lack of EphB3 receptor prevents bone loss in mouse models of osteoporosis

JOURNAL OF BONE AND MINERAL RESEARCH. Article. 39(7):1008-1024.
[doi:10.1093/jbmr/zjae075]

2022

Garcia-Ceca, J, Montero-Herradon, S, Gonzalez, A, Plaza, R, Zapata, AG (2022).

Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization

CELLULAR AND MOLECULAR LIFE SCIENCES. Article. 79(11):583-583.
[doi:10.1007/s00018-022-04610-w]

Sevilla-Movilla S, Fuentes P, Rodríguez-García Y, Arellano-Sánchez N, Krenn PW, de Val SI, Montero-Herradón S, García-Ceca J, Burdiel-Herencia V, Gardeta SR, Aguilera-Montilla N, Barrio-Alonso C, Crainiciuc G, Bouvard D, García-Pardo A, Zapata AG, Hidalgo A, Fässler R, Carrasco YR, Toribio ML, Teixidó J (2022).

ICAP-1 loss impairs CD8(+) thymocyte development and leads to reduced marginal zone B cells in mice.

EUROPEAN JOURNAL OF IMMUNOLOGY. Article. 52(8):1228-1242.
[doi:10.1002/eji.202149560]

Fernández-Santos ME, Garcia-Arranz M, Andreu EJ, García-Hernández AM, López-Parra M, Villarón E, Sepúlveda P, Fernández-Avilés F, García-Olmo D, Prosper F, Sánchez-Guijo F, Moraleda JM, Zapata AG (2022).

Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome.

Frontiers in Immunology. Review. 13:918565-918565.
[doi:10.3389/fimmu.2022.918565]

Zapata AG (2022).

Lympho-Hematopoietic Microenvironments and Fish Immune System.

Biology-Basel. Review. 11(5).
[doi:10.3390/biology11050747]

2021

Montero-Herradón S, Zapata AG (2021).

Delayed maturation of thymic epithelium in mice with specific deletion of ß-catenin gene in FoxN1 positive cells.

HISTOCHEMISTRY AND CELL BIOLOGY. Article. 156(4):315-332.
[doi:10.1007/s00418-021-02012-w]

Fañanas-Baquero S, Orman I, Becerra Aparicio F, Bermudez de Miguel S, Garcia Merino J, Yañez R, Fernandez Sainz Y, Sánchez R, Dessy-Rodríguez M, Alberquilla O, Alfaro D, Zapata A, Bueren JA, Segovia JC, Quintana-Bustamante O (2021).

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice.

HAEMATOLOGICA. Article. 106(6):1659-1670.
[doi:10.3324/haematol.2019.233924]

García-Bernal D, García-Arranz M, Yáñez RM, Hervás-Salcedo R, Cortés A, Fernández-García M, Hernando-Rodríguez M, Quintana-Bustamante Ó, Bueren JA, García-Olmo D, Moraleda JM, Segovia JC, Zapata AG (2021).

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy.

Frontiers in Cell and Developmental Biology. Article. 9:650664-650664.
[doi:10.3389/fcell.2021.650664]

Montero-Herradón S, García-Ceca J, Zapata AG (2021).

How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes?

Frontiers in Immunology. Editorial Material. 12:618216-618216.
[doi:10.3389/fimmu.2021.618216]

2020

García-Bernal, D, García-Arranz, M, Garcia-Guillen, AI, García-Hernández, AM, Blanquer, M, García-Olmo, D, Sackstein, R, Moraleda, JM, Zapata, AG (2020).

Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile

Frontiers in Cell and Developmental Biology. Article. 8.
[doi:10.3389/fcell.2020.584074]

García-Ceca, J, Montero-Herradón, S, Zapata, AG (2020).

Intrathymic Selection and Defects in the Thymic Epithelial Cell Development.

Cells. Review. 9(10).
[doi:10.3390/cells9102226]

Garcia-Ceca, J, Montero-Herradon, S, Zapata, AG (2020).

Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.

DEVELOPMENTAL DYNAMICS. Article. 249(10):1243-1258.
[doi:10.1002/dvdy.212]

Sánchez-Guijo F, García-Arranz M, López-Parra M, Monedero P, Mata-Martínez C, Santos A, Sagredo V, Álvarez-Avello JM, Guerrero JE, Pérez-Calvo C, Sánchez-Hernández MV, Del-Pozo JL, Andreu EJ, Fernández-Santos ME, Soria-Juan B, Hernández-Blasco LM, Andreu E, Sempere JM, Zapata AG, Moraleda JM, Soria B, Fernández-Avilés F, García-Olmo D, Prósper F (2020).

Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study.

EClinicalMedicine. Article. 25:100454-100454.
[doi:10.1016/j.eclinm.2020.100454]

Alfaro, D, Rodriguez-Sosa, MR, Zapata, AG (2020).

Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells

Journal of Clinical Medicine. Review. 9(2).
[doi:10.3390/jcm9020310]

Sanchez-Guijo, F, Garcia-Olmo, D, Prosper, F, Martinez, S, Zapata, A, Fernandez-Aviles, F, Toledo-Aral, JJ, Torres, M, Farinas, I, Badimon, L, Labandeira-Garcia, JL, Garcia-Sancho, J, Moraleda, JM, TerCel (2020).

Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research

CYTOTHERAPY. Review. 22(1):1-5.
[doi:10.1016/j.jcyt.2019.11.001]

2019

Muñoz JJ, Tobajas E, Juara S, Montero S, Zapata AG (2019).

FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis.

HISTOCHEMISTRY AND CELL BIOLOGY. Article. 152(6):397-413.
[doi:10.1007/s00418-019-01818-z]

2018

Alfaro, D, Zapata, AG (2018).

Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death

Stem Cell Research & Therapy. Article. 9(1):172-172.
[doi:10.1186/s13287-018-0912-3]

Montero-Herradon, S, Garcia-Ceca, J, Zapata, AG (2018).

Altered Maturation of Medullary TEC in EphB-Deficient Thymi Is Recovered by RANK Signaling Stimulation

Frontiers in Immunology. Article. 9:1020-1020.
[doi:10.3389/fimmu.2018.01020]

Muñoz JJ, Garcia-Ceca, J, Montero-Herradon, S, Sánchez Del Collado B, Alfaro, D, Zapata, A (2018).

Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi

Frontiers in Endocrinology. Article. 9:135-135.
[doi:10.3389/fendo.2018.00135]