Medical Chemistry Laboratory

Marin-Ramos, NI, Balabasquer, M, Ortega-Nogales, FJ, Torrecillas, IR, Gil-Ordonez, A, Marcos-Ramiro, B, Aguilar-Garrido, P, Cushman, I, Romero, A, Medrano, FJ, Gajate, C, Mollinedo, F, Philips, MR, Campillo, M, Gallardo, M, Martin-Fontecha, M, Lopez-Rodriguez, ML, Ortega-Gutierrez, S (2019).

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

JOURNAL OF MEDICINAL CHEMISTRY. Article. 62(13):6035-6046.
[doi:10.1021/acs.jmedchem.9b00145]

Marín-Ramos NI, Ortega-Gutiérrez S, López-Rodríguez ML (2019).

Blocking Ras inhibition as an antitumor strategy

SEMINARS IN CANCER BIOLOGY. Review. 54:91-100.
[doi:10.1016/j.semcancer.2018.01.017]

Gil-Ordóñez A, Martín-Fontecha M, Ortega-Gutiérrez S, López-Rodríguez ML (2018).

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

BIOCHEMICAL PHARMACOLOGY. Review. 157:18-32.
[doi:10.1016/j.bcp.2018.07.036]

Manterola, A, Bernal-Chico, A, Cipriani, R, Canedo-Antelo, M, Moreno-Garcia, A, Martin-Fontecha, M, Perez-Cerda, F, Sanchez-Gomez, MV, Ortega-Gutierrez, S, Brown, JM, Hsu, KL, Cravatt, B, Matute, C, Mato, S (2018).

Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

BIOCHEMICAL PHARMACOLOGY. Article. 157:189-201.
[doi:10.1016/j.bcp.2018.07.042]

Mecha, M, Feliu, A, Machin, I, Cordero, C, Carrillo-Salinas, F, Mestre, L, Hernandez-Torres, G, Ortega-Gutierrez, S, Lopez-Rodriguez, ML, de Castro, F, Clemente, D, Guaza, C (2018).

2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs

Glia. Article. 66(7):1447-1463.
[doi:10.1002/glia.23317]

Hernandez-Torres, G, Enriquez-Palacios, E, Mecha, M, Feliu, A, Rueda-Zubiaurre, A, Angelina, A, Martin-Cruz, L, Martin-Fontecha, M, Palomares, O, Guaza, C, Peña-Cabrera E, Lopez-Rodriguez, ML, Ortega-Gutierrez, S (2018).

Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-H T-1A Receptor in Native Cells of the Immune System

BIOCONJUGATE CHEMISTRY. Article. 29(6):2021-2027.
[doi:10.1021/acs.bioconjchem.8b00228]

Martin-Fontecha, M, Angelina, A, Ruckert, B, Rueda-Zubiaurre, A, Martin-Cruz, L, van de Veen, W, Akdis, M, Ortega-Gutierrez, S, Lopez-Rodriguez, ML, Akdis, CA, Palomares, O (2018).

A Fluorescent Probe to Unravel Functional Features of Cannabinoid Receptor CB1 in Human Blood and Tonsil Immune System Cells

BIOCONJUGATE CHEMISTRY. Article. 29(2):382-389.
[doi:10.1021/acs.bioconjchem.7b00680]

Camicia, F, Celentano, AM, Johns, ME, Chan, JD, Maldonado, L, Vaca, H, Di Siervi, N, Kamentezky, L, Gamo, AM, Ortega-Gutierrez, S, Martin-Fontecha, M, Davio, C, Marchant, JS, Rosenzvit, MC (2018).

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes

PLoS Neglected Tropical Diseases. Article. 12(2).
[doi:10.1371/journal.pntd.0006267]

García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI, Alén F, Botta J, McCormick PJ, Ballesteros JA, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML (2017).

A Positive Allosteric Modulator of the Serotonin 5-HT2c Receptor for Obesity

JOURNAL OF MEDICINAL CHEMISTRY. Article. 60(23):9575-9584.
[doi:10.1021/acs.jmedchem.7b00994]

Feliú A, Bonilla Del Río I, Carrillo-Salinas FJ, Hernández-Torres G, Mestre L, Puente N, Ortega-Gutiérrez S, López-Rodríguez ML, Grandes P, Mecha M, Guaza C (2017).

2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination

JOURNAL OF NEUROSCIENCE. Article. 37(35):8385-8398.
[doi:10.1523/JNEUROSCI.2900-16.2017]

Troupiotis-Tsaïlaki A, Zachmann J, González-Gil I, Gonzalez A, Ortega-Gutiérrez S, López-Rodríguez ML, Pardo L, Govaerts C (2017).

Ligand chain length drives activation of lipid G protein-coupled receptors

SCIENTIFIC REPORTS. Article. 7(1):2020-2020.
[doi:10.1038/s41598-017-02104-5]

Wagner R, Stübiger G, Veigel D, Wuczkowski M, Lanzerstorfer P, Weghuber J, Karteris E, Nowikovsky K, Wilfinger-Lutz N, Singer CF, Colomer R, Benhamú B, López-Rodríguez ML, Valent P, Grunt TW (2017).

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

Oncotarget. Article. 8(7):11600-11613.
[doi:10.18632/oncotarget.14591]

Artola M, Ruíz-Avila LB, Ramírez-Aportela E, Martínez RF, Araujo-Bazán L, Vázquez-Villa H, Martín-Fontecha M, Oliva MA, Martín-Galiano AJ, Chacón P, López-Rodríguez ML, Andreu JM, Huecas S (2017).

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

CHEMICAL SCIENCE. Article. 8(2):1525-1534.
[doi:10.1039/c6sc03792e]

Marín-Ramos NI, Piñar C, Vázquez-Villa H, Martín-Fontecha M, González Á, Canales Á, Algar S, Mayo PP, Jiménez-Barbero J, Gajate C, Mollinedo F, Pardo L, Ortega-Gutiérrez S, Viso A, López-Rodríguez ML (2017).

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling

CHEMISTRY-A EUROPEAN JOURNAL. Article. 23(7):1676-1685.
[doi:10.1002/chem.201604905]

González-Vera JA, Medina RA, Martín-Fontecha M, Gonzalez A, de la Fuente T, Vázquez-Villa H, García-Cárceles J, Botta J, McCormick PJ, Benhamú B, Pardo L, López-Rodríguez ML (2017).

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding

SCIENTIFIC REPORTS. Article. 7:41293-41293.
[doi:10.1038/srep41293]